8-CPT-cAMPAn efficient activator of cGK and cAMP-PK, and inhibitor of PDE

8-CPT-cAMP (CAS 93882-12-3)

8-CPT-cAMP | CAS 93882-12-3 is rated 5.0 out of 5 by 1.
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Synonym: 8-(4-Chlorophenylthio)-adenosine-3',5'-cyclic monophosphate, sodium salt
Application: An efficient activator of cGK and cAMP-PK, and inhibitor of PDE
CAS Number: 93882-12-3
Purity: ≥96%
Molecular Weight: 493.79
Molecular Formula: C16H14ClN5O6PS•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

8-CPT-cAMP is an efficient activator of cGKI (cyclic-GMP-dependent protein kinase) and PKA (cAMP-PK). Additionally, 8-CPT-cAMP is a robust inhibitor of PDE (cyclic GMP-specific phosphodiesterase) (IC50= 0.9 μM). cGMP-inhibited phosphodiesterase and Ca2+/calmodulin-dependent phosphodiesterase have been reported to hydrolyze 8-CPT-cAMP. 8-CPT-cAMP has been used in studies to analyze the signal-transduction pathways initiated by cAMP-PK and cGMP-PK. Research indicates that 8-CPT-cAMP can inhibit thrombin-induced phosphorylation mediated by protein kinase C and myosin light chain kinase.


References

1. Sandberg, M., et al. 1991. Biochem. J. 279: 521-527. PMID: 1659381

2. Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44: 2303-2306. PMID: 1335252

3. Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 1031-1035. PMID: 1310537

Usage :
Stock solutions should be divided into aliquots and stored at -20°C for up to 1 month.
Physical State :
Solid
Solubility :
Soluble in water (25 mg/mL).
Storage :
Store at -20° C
IC50 :
Activators of the Protein Kinase A-R1A (PKA-R1A) complex.: EC5050 = 32.68 nM; Activators of the Protein Kinase A-R2B (PKA-R2B) complex.: EC5050 = 50.49 nM
pK Values :
pKa: 0.96 in ethyl acetate (Predicted), pKb: 2.88 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23672705
MDL Number :
MFCD00057683
EC Number :
299-413-9
SMILES :
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=NC=N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=O)(O1)[O-].[Na+]

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Certificate of Analysis

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8-CPT-cAMP  Product Citations

See how others have used 8-CPT-cAMP. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 30755584  Zhao, X.|Wei, S.|Li, Z.|Lin, C.|Zhu, Z.|Sun, D.|Bai, R.|Qian, J.|Gao, X.|Chen, G.|Xu, Z.| et al. 2019. Cell Death Dis. 10: 127.

PMID: # 29111771  Ziesemer, S. et al. 2017. Am. J. Respir. Cell Mol. Biol.

PMID: # 25524737  Ghorbani, A. et al. 2015. Arch. Biochem. Biophys. 566: 58-66.

PMID: # 24610700  Wyatt, LA. et al. 2014. J. Comp. Neurol. 522: 2741-55.

PMID: # 22251095  Rossios, C. et al. 2012. Br. J. Pharmacol. 167: 775-86.

PMID: # 21982708  Sellayah, D. et al. 2011. Cell Metab. 14: 478-90.

PMID: # 20624391  Safa, M. et al. 2010. FEBS Lett. 584: 3492-8.

PMID: # 20534719  Shao, J. et al. 2010. Endocrinology. 151: 3728-37.

PMID: # 19773550  Zhang, Y. et al. 2009. J. Biol. Chem. 284: 32813-32826.

PMID: # 19237344  Yu, JZ. et al. 2009. J. Biol. Chem. 284: 10462-10472.

Citations 1 to 10 of 16 total

Is this product cell permeable?

Asked by: Jz28sail
Thank you for your question. Yes, sc-201569A, 8-CPT-cAMP is a lipophilic, cell-permeable cAMP analog.
Answered by: Chemical Support 5
Date published: 2017-04-17
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Rated 5 out of 5 by from Zhang Zhang, Y. et al. (PubMed 19773550) used 8-CPT-cAMP, an efficient activator of cyclic-GMP-dependent protein kinase (cGMP-PK) and cAMP-PK, to examine the induction of NT-PGC-1 by cAMP. -SCBT Publication Review
Date published: 2015-04-27
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