8-Bromoadenosine 3′,5′-cyclic monophosphateA membrane-permeable cAMP analog

8-Bromoadenosine 3′,5′-cyclic monophosphate (CAS 23583-48-4)

8-Bromoadenosine 3′,5′-cyclic monophosphate | CAS 23583-48-4 is rated 5.0 out of 5 by 1.
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Synonym: 8-Br-cAMP
Application: A membrane-permeable cAMP analog
CAS Number: 23583-48-4
Purity: ≥98%
Molecular Weight: 408.10
Molecular Formula: C10H11BrN5O6P
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Bromoadenosine 3',5'-cyclic monophosphate is a membrane-permeable cAMP analog. A cyclic nucleotide analog for the study of Ca2+ mediated pathways. Also, a potent activator of protein kinase which inhibits growth, decreases proliferation, increases differentiation and induces apoptosis of cultured cells. 8-Bromoadenosine 3',5'-cyclic monophosphate is an activator of PKA.


References

1. White, R.E. and Hartzell, H.C. 1988. Science. 239: 778-780. PMID: 2448878
2. Hartzell, H.C. and Fischmeister, R. 1986. Nature. 323: 273-275. PMID: 2429189
3. Corbin, J.D., et al. 1986. J. Biol. Chem. 261: 1208-1214. PMID: 3003061
4. Meyer, R.B. and Miller, J.P 1974. Life Sci. 14: 1019-1040. PMID: 4362776
5. Hei, Y.J., et al. 1991. Mol. Pharmacol. 39: 233-238. PMID: 1847496
6. Martin, T.F. and Kowalchyk, J.A. 1981. Science. 213: 1120-1122. PMID: 6267695
7. Chen, T.C., et al. 1998. Lab. Invest. 78: 165-174. PMID: 9484714

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in aqueous base, and 1 N NH4OH (50 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
32014
SMILES :
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(O1)O

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Certificate of Analysis

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What is the life span of 8-Bromoadenosine 3',5'-cyclic monophosphate after reconstitution?

Asked by: SCchem16
Thank you for your question. 8-Bromoadenosine 3',5'-cyclic monophosphate, sc-217493, will not be very stable after reconstitution so it is recommended it be frozen to prevent decomposition. It is always best to use solutions after they are made but should remain stable if stored frozen in the dark for 6 months.
Answered by: TechService7
Date published: 2017-01-11
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Rated 5 out of 5 by from Cantero Mdel Cantero Mdel, R. et al. (PubMed 26269590) reported that 8-Bromoadenosine 3',5'-cyclic monophosphate stimulated spontaneous endogenous polycystin-2 channel activity in the absence of the exogenous kinase. -SCBT Publication Review
Date published: 2015-04-19
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