8-Bromo-cADP-Ribose (8-Br-cADPR)An antagonist of cADPR

8-Bromo-cADP-Ribose (8-Br-cADPR) (CAS 151898-26-9)

8-Bromo-cADP-Ribose (8-Br-cADPR) | CAS 151898-26-9 is rated 5.0 out of 5 by 1.
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Application: An antagonist of cADPR
CAS Number: 151898-26-9
Purity: 95%
Molecular Weight: 620.19
Molecular Formula: C15H20BrN5O13P2
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Bromo-cADP-Ribose (8-Br-cADPR), a cell permeable antagonist of cADPR (sc-201512), has been shown to block cADPR from inducing Ca2+ release from sea-urchin-egg homogenates. cADPR has also been observed to regulate calcium release from the sarcoplasmic and endoplasmic reticulum. The antagonist displays the capacity to inhibit arrhythmogenic oscillations of intracellular Ca2+ in heart cells. Additionally, this agent has been reported to be an endogenous metabolite of β-NAD+.


References

1. Walseth, T.F., et al. 1993. Biochim. Biophys. Acta. 1178: 235-242. PMID: 8395888
2. Iino, S., et al. 1997. Circ. Res. 81: 879-884. PMID: 9351463
3. Rakovic, S., et al. 1999. J. Biol. Chem. 274: 17820-17827. PMID: 10364226
4. Cheung, D.W. 2003. Eur. J. Pharmacol. 458: 57-59. PMID: 12498907
5. Guse, A.H., et al. 2005. J. Biol. Chem. 280: 15952-15959. PMID: 15713671

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WA1900000
PubChem CID :
44134590
MDL Number :
MFCD00274402
SMILES :
C1C2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(OP(=O)(O1)O)OC5C(C(C(O5)CO)O)O

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8-Bromo-cADP-Ribose (8-Br-cADPR)  Product Citations

See how others have used 8-Bromo-cADP-Ribose (8-Br-cADPR). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 31244614  Roboon, J.|Hattori, T.|Ishii, H.|Takarada-Iemata, M.|Le, TM.|Shiraishi, Y.|Ozaki, N.|Yamamoto, Y.|Sugawara, A.|Okamoto, H.|Higashida, H.|Kitao, Y.|Hori, O.| et al. 2019. Front Cell Neurosci. 13: 258.

PMID: # 28295574  Hattori, T. et al. 2017. Glia. 65: 974-989.

PMID: # 17151266  Rogers, RC. et al. 2006. J. Neurosci. 26: 12642-12646.

PMID: # 16095628  Teggatz, EG. et al. 2005. Microvasc. Res. 70: 65-75.

PMID: # 15266023  Tliba, O. et al. 2004. Mol. Pharmacol. 66: 322-329.

PMID: # 12204658  Zhang, DX. et al. 2002. Microvasc. Res. 64: 339-348.

PMID: # 10642331  Geiger, J. et al. 2000. Hypertension. 35: 397-402.

PMID: # 10993745  Yu, JZ. et al. 2000. Am. J. Physiol. Heart Circ. Physiol. 279: H873-H881.

PMID: # 10097163  Reyes-Harde, M. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 4061-4066.

PMID: # 10364226  Rakovic, S. et al. 1999. J. Biol. Chem. 274: 17820-17827.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Rogers et al Rogers et al. (PubMed ID 17151266) used 8-Bromo-cADP-Ribose (8-BR-cADPR), an antagonist of intracellular cADPR, to regulate calcium storage within the cell by to suppressing TNF-induced amplification of ATP. -SCBT Publication Review
Date published: 2015-07-08
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