8-Amino AdenosineAn apoptosis inducer

8-Amino Adenosine (CAS 3868-33-5)

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Synonym: 8-Amino-D-adenosine
Application: An apoptosis inducer
CAS Number: 3868-33-5
Purity: ≥98%
Molecular Weight: 282.26
Molecular Formula: C10H14N6O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Amino Adenosine is a purine nucleoside analogwhich has a role in the induction of apoptosis in multiple myeloma.


References

Yan, Y., et al.: J. Biol. Chem., 274, 31917 (1999), Chang, L., et al.: Nature, 410, 37 (2001), Gandhi, V., et al.: Cancer Res., 61, 5474 (2001), Ravandi, F., et al.: Clin. Cancer Res., 9, 535 (2003),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, methanol, and water (2 mg/ml, clear (warmed)).
Storage :
Store at -20° C
Melting Point :
>185° C (dec.)
Boiling Point :
~747.1° C at 760 mmHg (Predicted)
Density :
~2.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.99 (Predicted)
IC50 :
Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70: IC50 = 9.4 µM; Binding affinity to HSP90: IC50 = > 400 µM
Ki Data :
HSP70: Ki= 4.46 µM; Adenosine A2a receptor : Ki= 24.1 µM (rat); Adenosine deaminase: Ki= 89.5 µM (Bos taurus)
pK Values :
pKa: 13.07 (Predicted), pKb: 5.48 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
96851
MDL Number :
MFCD00047230
SMILES :
C1=NC(=C2C(=N1)N(C(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N

Download SDS (MSDS)

Certificate of Analysis

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