8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt (8-CPT-2'-O-Me-cAMP• Na ) is a selective activator of cGKI α, cGKI β, and cGKII (cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II )as well as of CNG (cGMP-gated ion channels). The compounds higher activation potential as compared to cGMP, and retains excellent cell membrane permeability and phosphodiesterase stability. 8-CPT-2'-O-Me-cAMP • Na has been preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
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2. Butt, E., et al. 1992. Biochem. Pharmacol. 43: 2591-2600. PMID: 1321624
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