8-(4-Chlorophenylthio)guanosine 3prime,5prime-cyclic Monophosphate sodium saltA selective activator of cGMP-dependent protein kinase

8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt (CAS 51239-26-0)

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Synonym: 8-pCPT-cGMP•Na
Application: A selective activator of cGMP-dependent protein kinase
CAS Number: 51239-26-0
Purity: ≥99%
Molecular Weight: 509.8
Molecular Formula: C16H14ClN5O7PS Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt (8-CPT-2'-O-Me-cAMP• Na ) is a selective activator of cGKI α, cGKI β, and cGKII (cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II )as well as of CNG (cGMP-gated ion channels). The compounds higher activation potential as compared to cGMP, and retains excellent cell membrane permeability and phosphodiesterase stability. 8-CPT-2'-O-Me-cAMP • Na has been preferred alternative to unsuitable analogs such as dibutyryl-cGMP.


References

1. Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. U.S.A .89: 1031-1035. PMID: 1310537
2. Butt, E., et al. 1992. Biochem. Pharmacol. 43: 2591-2600. PMID: 1321624

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml). Insoluble in acetone.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23679064
MDL Number :
MFCD00674888
SMILES :
[Na+].NC1=NC2=C(N=C(SC3=CC=C(Cl)C=C3)N2[C@@H]2O[C@@H]3COP([O-])(=O)O[C@H]3[C@H]2O)C(=O)N1

Download SDS (MSDS)

Certificate of Analysis

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