8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis, arachidonic acid induced platelet aggregation, Cox (IC50 = 14 μM), human 12-LO (IC50 = 0.46 μM), 5-LO (IC50 = 25 μM), and the actions of slow-reacting substance of anaphylaxis (SRS-A) (IC50 = 10 μM).
1 Goetz, J.M., Sprecher, H., Cornwell, D.G., et al. Inhibition of prostaglandin biosynthesis by triynoic acids. Prostaglandins 12(2) 187-192 (1976). 2 Sun, F.F., McGuire, J.C., Morton, D.R., et al. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. Prostaglandins 21(2) 333-343 (1981). 3 Jakschik, B.A., DiSantis, D.M., Sankarappa, S.K., et al. Modulation of leukotriene formation by various acetylenic acids. (1982).
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