8,11,14-Eicosatriynoic AcidCAS: 34262-64-1
MF: C20H28O2
MW: 300.4
A Cox, 12-LO, and 5-LO inhibitor.

8,11,14-Eicosatriynoic Acid (CAS 34262-64-1)

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Synonym: 8,11,14-ETI
Application: A Cox, 12-LO, and 5-LO inhibitor
CAS Number: 34262-64-1
Molecular Weight: 300.4
Molecular Formula: C20H28O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis, arachidonic acid induced platelet aggregation, Cox (IC50 = 14 μM), human 12-LO (IC50 = 0.46 μM), 5-LO (IC50 = 25 μM), and the actions of slow-reacting substance of anaphylaxis (SRS-A) (IC50 = 10 μM).


References

1 Goetz, J.M., Sprecher, H., Cornwell, D.G., et al. Inhibition of prostaglandin biosynthesis by triynoic acids. Prostaglandins 12(2) 187-192 (1976). 2 Sun, F.F., McGuire, J.C., Morton, D.R., et al. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. Prostaglandins 21(2) 333-343 (1981). 3 Jakschik, B.A., DiSantis, D.M., Sankarappa, S.K., et al. Modulation of leukotriene formation by various acetylenic acids. (1982).

Physical State :
Solid
Solubility :
Soluble in water (0.15 mg/ml at 25.0° C), ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), and PBS (pH 7.2, ~0.15 mg/ml).
Storage :
Store at -20° C
Melting Point :
180.12° C (Predicted)
Boiling Point :
~469.6° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
12-LO: IC50 = 0.46 µM (human); SRS-A: IC50 = 10 µM; Cox: IC50 = 14 µM; 5-LO: IC50 = 25 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9543604
MDL Number :
MFCD00156106
SMILES :
CCCCCC#CCC#CCC#CCCCCCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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