7-NitroindazoleA specific inhibitor of neural nitric oxide synthase (nNOS)

7-Nitroindazole (CAS 2942-42-9)

7-Nitroindazole | CAS 2942-42-9 is rated 5.0 out of 5 by 2.
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Synonym: 7-NI
Application: A specific inhibitor of neural nitric oxide synthase (nNOS)
CAS Number: 2942-42-9
Purity: ≥97%
Molecular Weight: 163.13
Molecular Formula: C7H5N3O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling. 7-nitroindazole thus inhibits the cell signaling process.


References

1. Kelly, P.A., et al. 1995. J. Cereb. Blood Flow Metab. 15: 766-773. PMID: 7545690
2. Schulz, J.B., et al. 1995. J. Neurochem. 64: 936-939. PMID: 7530297
3. Itzhak, Y. and Ali, S.F. 1996. J. Neurochem. 67: 1770-1773. PMID: 8858965
4. Mutlu, O., et al. 2010. Fundam Clin Pharmacol. [Epub ahead of print]. PMID: 20608991

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol, methanol, and acetone.
Storage :
Store at -20° C
Melting Point :
217.37° C (Predicted)
Boiling Point :
383° C
Density :
1.53 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
Nitric-oxide synthase: IC50 = 0.11 µM (Rattus norvegicus)
pK Values :
pKa: 10.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NK7962200
PubChem CID :
1893
MDL Number :
MFCD00022789
EC Number :
220-934-4
Beilstein Registry :
6809
SMILES :
C1=CC2=C(C(=C1)[N+](=O)[O-])NN=C2

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7-Nitroindazole  Product Citations

See how others have used 7-Nitroindazole. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26782056  Harraz, MM. et al. 2016. Molecular psychiatry. 21: 313-9.

PMID: # 15687494  Zaccagnini, G. et al. 2005. J. Biol. Chem. 280: 14790-14798.

PMID: # 15110495  Damy, T. et al. 2004. Lancet. 363: 1365-1367.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
Rated 5 out of 5 by from Zaccagnini Zaccagnini, et. al. (PubMed ID 15687494) used product sc-3569, 7-Nitroindazole, to inhibit NOS in differentiated C2C12 and porliferating HUVECs (in the presence & absence of angiogenic factors). -Product Review
Date published: 2015-06-08
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