7-Ethoxyresorufin CAS: 5725-91-7
MF: C14H11NO3
MW: 241.24
A fluorometric inhibitor of vasorelaxant responses.

7-Ethoxyresorufin (CAS 5725-91-7)

7-Ethoxyresorufin | CAS 5725-91-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 7-ER
Application: 7-Ethoxyresorufin is a fluorometric inhibitor of vasorelaxant responses
CAS Number: 5725-91-7
Purity: ≥98%
Molecular Weight: 241.24
Molecular Formula: C14H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.


References

1. Donato, M.T., et al. 1993. Anal. Biochem. 213: 29-33. PMID: 8238878
2. Oyekan, A.O., et al. 1994. J. Pharmacol. Exp. Ther. 268: 262-269. PMID: 8301566
3. Dutton, D.R., et al. 1989. Arch. Biochem. Biophys. 268: 605-616. PMID: 2464338
4. Jiang, H.B. and Ichikawa, Y. 1999. Life Sci. 65: 1257-1264. PMID: 10503941

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/mL), ethanol (5 mg/mL), chloroform, dichloromethane, DMF (5 mg/mL), alcohols, and methanol. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
223-225° C (lit.)
Boiling Point :
~389.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.62
Fluoresence :
λex 464 nm, λem 540 nm in methanol; λex 571 nm, λem 585 nm in dealkylase
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00037661
Beilstein Registry :
225973
SMILES :
CCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2

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Certificate of Analysis

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7-Ethoxyresorufin (CAS 5725-91-7)  Product Citations

See how others have used 7-Ethoxyresorufin (CAS 5725-91-7). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 31111189  Mescher, M. et al. 2019. Arch. Toxicol. 93: 1917-1926.

PMID: # 29145161  Xie, W. et al. 2017. Ecotoxicol. Environ. Saf. 149: 10-18.

PMID: # 22749116  Aravalli, RN. et al. 2012. Veterinary journal (London, England : 1997). 194: 369-74.

PMID: # 29666456  Sci Rep. 6103.

PMID: # 32017483  Cell. Physiol. Biochem. 54: 126-141.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Beg MU; et al Beg MU; et al. (PubMed ID: 26409815) utilized 7-Ethoxyresorufin as a fluorescent aromatic compound to measure the seasonal exposure of petroleum hydrocarbons in yellow fin seabream (Acanthopagrus latus) and tonguesolj. -SCBT Publication Review
Date published: 2015-06-23
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