7-epi-Taxol is a paclitaxel binds to tubulin, interfering with the normal function of microtubule. As a result the cell is unable to use its cytoskeleton in a flexible manner. The cell's dynamic instability is interrupted. The compound 7-epi-Taxol has been isolated from Taxus brevifolia. 7-epi-Taxol also displays antineoplastic properties.
1. Kingston, D.G. 1991. Pharmacol. Ther. 52: 1-34. PMID: 1687170 2. Wiley, R.A., et al. 1993. Med Res Rev. 13: 327-384. PMID: 8483337 3. Dordunoo, S.K., et al. 1996. J. Pharm. Pharmacol. 48: 782-789. PMID: 8887725 4. Kumar, N. 1981. J. Biol. Chem. 256: 10435-10441. PMID: 6116707 5. Horwitz, S.B. 1992. Trends Pharmacol. Sci. 13: 134-136. PMID: 1350385
Soluble in chloroform, and methanol.
Store at -20° C
168-170° C (dec.)
892.1-1022.1° C at 760 mmHg (Predicted)
1.40 g/cm3 (Predicted)
n20D 1.64 (Predicted)
α20/D -65.6°, c = 0.1 in methanol
KB: IC50 = 0.002 µg/ml (human)
pKa: 11.9 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
FraierFraier, D. et al. (PubMed 9542121) developed a sensitive and selective high-performance liquid chromatographic method for the determination of PNU 166945, a polymer-bound paclitaxel derivative, free paclitaxel, and 7-epi-Taxol in dog plasma and urine. -SCBT Publication Review
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