7-epi-TaxolAn antineoplastic compound

7-epi-Taxol (CAS 105454-04-4)

7-epi-Taxol | CAS 105454-04-4 is rated 5.0 out of 5 by 1.
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Synonym: 7-Epipaclitaxel; 7-Epitaxol; 7-epi-Paclitaxel; Epitaxol
Application: An antineoplastic compound
CAS Number: 105454-04-4
Purity: ≥95%
Molecular Weight: 853.91
Molecular Formula: C47H51NO14
* Refer to Certificate of Analysis for lot specific data (including water content).
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7-epi-Taxol is a paclitaxel binds to tubulin, interfering with the normal function of microtubule. As a result the cell is unable to use its cytoskeleton in a flexible manner. The cell's dynamic instability is interrupted. The compound 7-epi-Taxol has been isolated from Taxus brevifolia. 7-epi-Taxol also displays antineoplastic properties.


References

1. Kingston, D.G. 1991. Pharmacol. Ther. 52: 1-34. PMID: 1687170
2. Wiley, R.A., et al. 1993. Med Res Rev. 13: 327-384. PMID: 8483337
3. Dordunoo, S.K., et al. 1996. J. Pharm. Pharmacol. 48: 782-789. PMID: 8887725
4. Kumar, N. 1981. J. Biol. Chem. 256: 10435-10441. PMID: 6116707
5. Horwitz, S.B. 1992. Trends Pharmacol. Sci. 13: 134-136. PMID: 1350385

Physical State :
Solid
Derived From :
Taxus brevifolia
Solubility :
Soluble in chloroform, and methanol.
Storage :
Store at -20° C
Melting Point :
168-170° C (dec.)
Boiling Point :
892.1-1022.1° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Optical Activity :
α20/D -65.6°, c = 0.1 in methanol
IC50 :
KB: IC50 = 0.002 µg/ml (human)
pK Values :
pKa: 11.9 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
184492
MDL Number :
MFCD07783713
SMILES :
CC1=C2[C@H](C(=O)[C@@]3([C@@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Fraier Fraier, D. et al. (PubMed 9542121) developed a sensitive and selective high-performance liquid chromatographic method for the determination of PNU 166945, a polymer-bound paclitaxel derivative, free paclitaxel, and 7-epi-Taxol in dog plasma and urine. -SCBT Publication Review
Date published: 2015-06-24
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