Molecular structure of 7-Deaza-2′-C-methyladenosine, CAS Number: 443642-29-3
7-Deaza-2′-C-methyladenosine (CAS 443642-29-3)
See product citations (4)
Alternate Names:
7-Deaza-2′-C-methyl-D-adenosine
CAS Number:
443642-29-3
Molecular Weight:
280.28
Molecular Formula:
C12H16N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Deaza-2′-C-methyladenosine is a modified nucleoside that functions as an inhibitor of RNA methylation. It acts by interfering with the methylation process of RNA. 7-Deaza-2′-C-Methyladenosine disrupts the normal methylation pattern of RNA, leading to altered RNA structure and function. By inhibiting RNA methylation, 7-Deaza-2′-C-methyladenosine can impact various cellular processes that rely on properly methylated RNA, such as RNA stability, translation, and protein synthesis. Its mechanism of action involves binding to the RNA methyltransferase enzyme, thereby preventing the transfer of methyl groups to RNA molecules.
7-Deaza-2′-C-methyladenosine (CAS 443642-29-3) References
- Nucleoside inhibitors of tick-borne encephalitis virus. | Eyer, L., et al. 2015. Antimicrob Agents Chemother. 59: 5483-93. PMID: 26124166
- The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model. | Zmurko, J., et al. 2016. PLoS Negl Trop Dis. 10: e0004695. PMID: 27163257
- Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals. | Lanko, K., et al. 2017. Antiviral Res. 145: 82-86. PMID: 28736077
- Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness. | Eyer, L., et al. 2017. J Virol. 91: PMID: 28814513
- A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea. | Van Dycke, J., et al. 2018. J Infect Dis. 218: 1753-1758. PMID: 30085019
- Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals. | Tricot, T., et al. 2018. PLoS One. 13: e0209097. PMID: 30566505
- Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection. | Eyer, L., et al. 2019. Antimicrob Agents Chemother. 63: PMID: 30642926
- Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication. | Vincetti, P., et al. 2019. ACS Med Chem Lett. 10: 558-563. PMID: 30996796
- A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice. | Jacobs, S., et al. 2019. Int J Mol Sci. 20: PMID: 31032814
- An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. | Eyer, L., et al. 2019. J Virol. 93: PMID: 31142664
- 7-Deaza-7-fluoro-2'-C-methyladenosine inhibits Zika virus infection and viral-induced neuroinflammation. | Del Sarto, JL., et al. 2020. Antiviral Res. 180: 104855. PMID: 32574688
- Cytidine nucleoside analog is an effective antiviral drug against Trichomonasvirus. | Narayanasamy, RK., et al. 2022. J Microbiol Immunol Infect. 55: 191-198. PMID: 34479802
- Competing interests during the key N-glycosylation of 6-chloro-7-deaza-7-iodopurine for the synthesis of 7-deaza-2'-methyladenosine using Vorbrüggen conditions. | Naciuk, FF., et al. 2023. Front Chem. 11: 1163486. PMID: 37035111
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Deaza-2′-C-methyladenosine, 5 mg | sc-284810 | 5 mg | $204.00 | |||
7-Deaza-2′-C-methyladenosine, 10 mg | sc-284810A | 10 mg | $408.00 | |||
7-Deaza-2′-C-methyladenosine, 25 mg | sc-284810B | 25 mg | $867.00 | |||
7-Deaza-2′-C-methyladenosine, 50 mg | sc-284810C | 50 mg | $1428.00 | |||
7-Deaza-2′-C-methyladenosine, 100 mg | sc-284810D | 100 mg | $2550.00 | |||
7-Deaza-2′-C-methyladenosine, 250 mg | sc-284810E | 250 mg | $4590.00 |