7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin dihydrochloride is a chemically-modified forskolin with greater stability and water solubility than the parent compound. 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin dihydrochloride activates A cyclase (adenylate cyclase) and inhibits 5HT-stimulated inositol phosphate accumulation in muscle cells (smooth).
Yang, C.M., et al. 1999. Cell Signal. 11, 697. Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880. Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255. Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.
Soluble in water (12 mg/ml), and methanol.
Store at -20° C
685.7° C at 760 mmHg (Predicted)
n20D 1.57 (Predicted)
A cyclase: EC5050 = 13 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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