![7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride (CAS 115116-37-5) - chemical structure image](https://media.scbt.com/product/7-deacetyl-7-o-n-methylpiperazino-gamma-butyryl-forskolin-dihydrochloride-115116-37-5-structure_08_17_b_81793.jpg)
![7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride (CAS 115116-37-5) - chemical structure image](https://media.scbt.com/product/7-deacetyl-7-o-n-methylpiperazino-gamma-butyryl-forskolin-dihydrochloride-115116-37-5-structure_08_17_t_81793.jpg "Molecular structure of 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride, CAS Number: 115116-37-5")
Molecular structure of 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride, CAS Number: 115116-37-5
7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride (CAS 115116-37-5)
Alternate Names:
L-858051; 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one; Adenylate cyclase activator
Application:
7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride is a modified forskolin that activates adenylate cyclase
CAS Number:
115116-37-5
Molecular Weight:
609.6
Molecular Formula:
C29H48N2O7•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin dihydrochloride is a chemically-modified forskolin with greater stability and water solubility than the parent compound. 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin dihydrochloride activates A cyclase (adenylate cyclase) and inhibits 5HT-stimulated inositol phosphate accumulation in muscle cells (smooth).
7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride (CAS 115116-37-5) References
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- Adenosine receptor-adenylate cyclase system in the trout testis: involvement in the regulation of germ cell proliferation. | Loir, M. 2001. Mol Reprod Dev. 58: 307-17. PMID: 11170272
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- Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. | Funaki, C., et al. 2007. Am J Physiol Cell Physiol. 293: C1551-60. PMID: 17687004
- Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. | Haj Slimane, Z., et al. 2014. Cardiovasc Res. 102: 97-106. PMID: 24550350
- Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics. | Moore, BS., et al. 2016. Proc Natl Acad Sci U S A. 113: 13069-13074. PMID: 27799542
- Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells. | Belacel-Ouari, M., et al. 2017. Cell Signal. 35: 118-128. PMID: 28389413
- Contribution of BKCa channels to vascular tone regulation by PDE3 and PDE4 is lost in heart failure. | Idres, S., et al. 2019. Cardiovasc Res. 115: 130-144. PMID: 29939224
- Regulation of calcium channel current in A7r5 vascular smooth muscle cells by cyclic nucleotides. | Lorenz, JN., et al. 1994. Am J Physiol. 266: C1656-63. PMID: 8023895
- Regulation of 5-hydroxytryptamine-induced calcium mobilization by cAMP-elevating agents in cultured canine tracheal smooth muscle cells. | Yang, C., et al. 1996. Pflugers Arch. 432: 708-16. PMID: 8764973
- Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells. | Luo, SF., et al. 1997. Cell Signal. 9: 159-67. PMID: 9113415
- Effect of forskolin on endothelin-induced phosphoinositide hydrolysis and calcium mobilization in cultured canine tracheal smooth muscle cells. | Yang, CM., et al. 1998. J Auton Pharmacol. 18: 213-21. PMID: 9788291
Activator of:
A cyclase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride, 5 mg | sc-221624 | 5 mg | $510.00 |