7-Amino-4-trifluoromethylcoumarinFor the fluorometric assay of proteolytic enzymes in biological fluids

7-Amino-4-trifluoromethylcoumarin (CAS 53518-15-3)

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Synonym: AFC
Application: For the fluorometric assay of proteolytic enzymes in biological fluids
CAS Number: 53518-15-3
Molecular Weight: 229.2
Molecular Formula: C10H6F3NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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7-Amino-4-trifluoromethylcoumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.


References

1. M. Zimmermann et al. Anal. Biochem. 70, 258, (1976)

Appearance :
Powder
Physical State :
solid
Solubility :
Soluble in DMSO (25 mg/ml), DMF (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
221-222° C (lit.)
Boiling Point :
314.62° C at 760 mmHg (Predicted)
Density :
1.52 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
Beta Lactamase: IC50 = 4.77 µM (Pseudomonas aeruginosa); CHO: IC50 >49.7 µM (Cricetulus griseus); TLR9: IC50 = 8.42 µM (human)
Fluoresence :
λex 380 nm, λem 500 nm in DMSO
pK Values :
pKb: 1.12 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
100641
MDL Number :
MFCD00006858
EC Number :
258-599-1
Beilstein Registry :
4456797
SMILES :
C1=CC2=C(C=C1N)OC(=O)C=C2C(F)(F)F

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Certificate of Analysis

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7-Amino-4-trifluoromethylcoumarin  Product Citations

See how others have used 7-Amino-4-trifluoromethylcoumarin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22753480  Solier, S. et al. 2012. Proc. Natl. Acad. Sci. U.S.A. 109: 12866-12872.

PMID: # 23071775  Kumar, R. et al. 2012. PLoS ONE. 7: -.

Citations 1 to 2 of 2 total
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