7-Amino-3-vinyl-3-cephem-4-carboxylic Acid (CAS 79349-82-9)

7-Amino-3-vinyl-3-cephem-4-carboxylic acid is a key intermediate in the synthesis of various cephalosporin antibiotics. Its mechanism of action involves the beta-lactam ring, which mimics the D-Ala-D-Ala moiety of peptidoglycan precursors, allowing it to bind to and inhibit penicillin-binding proteins (PBPs). This inhibition prevents the cross-linking of peptidoglycan strands, which is essential for bacterial cell wall integrity, leading to cell lysis and death. In research, 7-amino-3-vinyl-3-cephem-4-carboxylic acid is used to study the biochemical pathways involved in beta-lactam antibiotic resistance, particularly the role of PBPs and beta-lactamases. Researchers employ this compound to investigate the structure-activity relationships of cephalosporins, optimizing the antibiotic properties by modifying the 3-vinyl and 7-amino positions. This work helps in developing novel cephalosporin derivatives with enhanced efficacy and resistance to beta-lactamases. Additionally, it serves as a model compound in studying the synthesis and functionalization of beta-lactam antibiotics, contributing to the broader understanding of antibiotic action and resistance mechanisms.