7,7-Dimethyleicosadienoic Acid (DEDA)An inhibitor of PLA2, sPLA2, and 5-LO

7,7-Dimethyleicosadienoic Acid (DEDA) (CAS 89560-01-0)

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Application: An inhibitor of PLA2, sPLA2, and 5-LO
CAS Number: 89560-01-0
Purity: 98%
Molecular Weight: 336.6
Molecular Formula: C22H40O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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7,7-Dimethyleicosadienoic Acid (DEDA) is an arachidonic acid analog that inhibits PLA2 (phospholipase A2). 7,7-Dimethyleicosadienoic Acid (DEDA) is reported to inhibit SRS-A biosynthesis occurring in peritoneal cells. This compound has been found to also inhibit P388D1 cell PLA2 and snake venom PLA2. DEDA has been shown to selectively inhibit human recombinant sPLA2 over cPLA2. This compound also weakly inhibits 5-LO (5-lipoxygenase).


References

1. Welton, A.F., et al. 1984. J. Pharmacol. Exp. Ther. 228: 57-64. PMID: 6198511
2. Cohen, N., et al. 1984. Prostaglandins. 27: 553-562. PMID: 6427852
3. Hope, W.C., et al. 1993. Agents Actions. 39: C39-C42. PMID: 8273580

Appearance :
Viscous oil
Physical State :
Liquid
Solubility :
Soluble in 100% ethanol, methanol, and DMSO.
Storage :
Store at -20° C
Refractive Index :
n20D 1.48 (Predicted)
IC50 :
PLA2: IC50 = 16 µM (P388D1 cell); PLA2: IC50 = 14 µM (snake venom); sPLA2: IC50 = 5.8 µM (human recombinant); 5-lipoxygenase: IC50 = 56 µM (RBL-l cells)
pK Values :
pKa: 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5312331
MDL Number :
MFCD00133010
SMILES :
CCCCCCCCCCC/C=C\\C(C)(C)/C=C\\CCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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