7,12-Dimethylbenz[a]anthraceneA carcinogen activated by microsomal enzymes

7,12-Dimethylbenz[a]anthracene (CAS 57-97-6)

7,12-Dimethylbenz[a]anthracene | CAS 57-97-6 is rated 5.0 out of 5 by 2.
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Synonym: DMBZA; DMBA
Application: A carcinogen activated by microsomal enzymes
CAS Number: 57-97-6
Purity: ≥98%
Molecular Weight: 256.34
Molecular Formula: C20H16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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7,12-Dimethylbenz[a]anthracene is a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction.


References

Huggins, C., et al.: Proc. Nat. Acad. Sci. U.S.A., 58, 2253 (1967), Dipple, A., et al.: N. Cancer Res., 43, 4123 (1983),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in toluene (50 mg/ml), acetone, chloroform, dichloromethane, ethanol, diethyl ether, n-octanol, and hot water (very slightly). Insoluble in cold water.
Storage :
Store at room temperature
Melting Point :
122-123° C (lit.)
Boiling Point :
463.46° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
Optical Activity :
α20/D 1.50°
Fluoresence :
λex 440 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CW3850000
PubChem CID :
6001
Merck Index :
14: 3235
MDL Number :
MFCD00003600
EC Number :
200-359-5
Beilstein Registry :
1912135
SMILES :
CC1=C2C=CC3=CC=CC=C3C2=C(C4=CC=CC=C14)C

Download SDS (MSDS)

Certificate of Analysis

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7,12-Dimethylbenz[a]anthracene  Product Citations

See how others have used 7,12-Dimethylbenz[a]anthracene. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30126855  Nassan, MA. et al. 2018. Biosci. Rep.

PMID: # 29368698  Wang, D. et al. 2018. Med. Sci. Monit. 24: 486-502.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Nice one I bought 1g of DMBA for my post graduate student. She's so grateful and happy because she is going to start her bench work.
Date published: 2019-03-29
Rated 5 out of 5 by from Purushothaman A; et al Purushothaman A; et al. (PubMed ID: 26416955) utilized 7,12-Dimethylbenz[a]anthracene to induce breast cancer in rats. -SCBT Publication Review
Date published: 2015-04-11
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