6prime-Iodoresiniferatoxin CAS: 335151-55-8
MF: C37H39IO9
MW: 754.61
A partial, high affinity TRPV1 (VR1) vanilloid receptor agonist.

6′-Iodoresiniferatoxin (CAS 335151-55-8)

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Alternate Names: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester
Application: 6′-Iodoresiniferatoxin is a partial, high affinity TRPV1 (VR1) vanilloid receptor agonist
CAS Number: 335151-55-8
Purity: >99%
Molecular Weight: 754.61
Molecular Formula: C37H39IO9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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6'-Iodoresiniferatoxin is a high affinity VR1 (TRPV1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.


References

1. McDonnell, M.E., et al. 2002. Bioorg. Med. Chem. Lett. 12: 1189-1192. PMID: 11934585

Appearance :
Film
Physical State :
Solid
Solubility :
Soluble in ethanol, and DMSO.
Storage :
Store at -20° C
Boiling Point :
812.97° C at 760 mmHg (Predicted)
Density :
1.56 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
TRPV1: EC5050 = 0.13 µM (human)
Ki Data :
TRPV1: Ki= 0.71 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD09971005
SMILES :
C[[email protected]@H]1C[[email protected]]2([[email protected]]3C4[[email protected]]1([[email protected]@H]5C=C(C(=O)[[email protected]]5(CC(=C4)COC(=O)CC6=CC(=C(C=C6I)O)OC)O)C)O[[email protected]](O3)(O2)CC7=CC=CC=C7)C(=C)C

Download SDS (MSDS)

Certificate of Analysis

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