6-O-MethylguanineA methylated guanine with antitumor properties

6-O-Methylguanine (CAS 20535-83-5)

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Application: A methylated guanine with antitumor properties
CAS Number: 20535-83-5
Molecular Weight: 165.15
Molecular Formula: C6H7N5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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6-O-Methylguanine is a methylated guanine with antitumor properties.


References

1. Taioli, E., et al., 1997. Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 6(7): 517-22. PMID: 9232339
2. Staretz, M E., et al., 1997. Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats. Carcinogenesis. 18(9): 1715-22. PMID: 9328166
3. Henderson, Colin J., et al., 2003. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. The Journal of biological chemistry. 278(15): 13480-6. PMID: 12566435
4. Jalas, John R., et al., 2003. Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical research in toxicology. 16(6): 794-806. PMID: 12807363
5. Su, Ting., et al., 2004. Regulation of the cytochrome P450 2A genes. Toxicology and applied pharmacology. 199(3): 285-94. PMID: 15364544

Physical State :
Solid
Solubility :
Soluble in DMSO and Water
Storage :
Store at -20° C
Melting Point :
220-2250°C (lit.)(dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
65275
SMILES :
COC1=NC(=NC2=C1NC=N2)N

Download SDS (MSDS)

Certificate of Analysis

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