6-Aminonicotinamide

6-Aminonicotinamide (CAS 329-89-5)

6-Aminonicotinamide | CAS 329-89-5 is rated 5.0 out of 5 by 1.
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Synonym: 6-Aminopyridine-3-carboxamide
Application: A PGD inhibitor and apoptosis inducer
CAS Number: 329-89-5
Purity: ≥98%
Molecular Weight: 137.14
Molecular Formula: C6H7N3O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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6-Aminonicotinamide is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.


References

1. Lange, K., et al., 1970. Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide. Naunyn-Schmiedebergs Archiv für Pharmakologie. 267(2): 177-80. PMID: 4394804
2. Street, J C., et al., 1997. Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. Cancer research. 57(18): 3956-62. PMID: 9307279
3. Belfi, C A., et al., 1999. Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation. Biochemical and biophysical research communications. 257(2): 361-8. PMID: 10198218
4. Zuurbier, C J., et al., 2004. Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart. Cardiovascular research. 62(1): 145-53. PMID: 15023561
5. Penkowa, Milena., et al., 2004. Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide. Journal of neuroscience research. 77(1): 35-53. PMID: 15197737

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
245-248° C (lit.)
Boiling Point :
~381.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
9500
SMILES :
C1=CC(=NC=C1C(=O)N)N

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6-Aminonicotinamide  Product Citations

See how others have used 6-Aminonicotinamide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27011353  Sanman, LE. et al. 2016. Elife. 5:

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Bai Bai, et al. (PubMed ID 25050110) used 6-Aminonicotinamide, an analogue of niacin and inhibitor of poly (ADP-ribose), to up-regulate GRP78 in macrophages. -SCBT Publication Review
Date published: 2015-01-25
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