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6-Aminonicotinamide is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.
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2. Street, J C., et al., 1997. Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. Cancer research. 57(18): 3956-62. PMID: 9307279
3. Belfi, C A., et al., 1999. Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation. Biochemical and biophysical research communications. 257(2): 361-8. PMID: 10198218
4. Zuurbier, C J., et al., 2004. Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart. Cardiovascular research. 62(1): 145-53. PMID: 15023561
5. Penkowa, Milena., et al., 2004. Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide. Journal of neuroscience research. 77(1): 35-53. PMID: 15197737
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