6-Amidino-2-naphthol HydrochlorideA metabolite of Nafamostat Mesylate (NM)

6-Amidino-2-naphthol Hydrochloride (CAS 66217-10-5)

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Application: A metabolite of Nafamostat Mesylate (NM)
CAS Number: 66217-10-5
Molecular Weight: 222.67
Molecular Formula: C11H11ClN2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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6-Amidino-2-naphthol Hydrochloride is the hydrochloride salt preparation of 6-Amidino-2-naphthol, a major metabolite of the serine-protease inhibitor Nafamostat mesylate (sc-201307). This metabolite has been described in studies probing the inhibitory action of Nafamostat and is described to be a catalytically inert species, demonstrating no effect upon prostasin secretion in M-1 cells and in rats which Nafamostat was shown to inhibit.


References

1. Muto, S., et al. 1994. Br. J. Pharmacol. 111: 173-178. PMID: 8012693
2. Iwashita, K., et al. 2003. J. Am. Soc. Nephrol. 14: 11-16. PMID: 12506133

Physical State :
Solid
Solubility :
Soluble in water, and methanol.
Storage :
Store at -20° C
Melting Point :
263-265° C
Boiling Point :
398° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11096199
MDL Number :
MFCD04039384
SMILES :
Cl.Oc1ccc2cc(ccc2c1)C(=N)N

Download SDS (MSDS)

Certificate of Analysis

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