6,7-Dinitroquinoxaline-2,3-dione (DNQX)A non-NMDA receptor complex antagonist

6,7-Dinitroquinoxaline-2,3-dione (DNQX) (CAS 2379-57-9)

6,7-Dinitroquinoxaline-2,3-dione (DNQX) | CAS 2379-57-9 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200444, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 82ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: FG 9041
Application: A non-NMDA receptor complex antagonist
CAS Number: 2379-57-9
Purity: ≥98%
Molecular Weight: 252.14
Molecular Formula: C8H4N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

DNQX is a non-N-methyl-D-aspartate (non-NMDA) receptor complex antagonist. The compound has been shown to attenuate JNK3 activation and has been shown not to stimulate a robust long-term potentiation in hippocampul studies. 6,7-Dinitroquinoxaline-2,3-dione (DNQX) is an inhibitor of GluR.


References

1. Muller, D., et al. 1988. Science. 242: 1694-1697. PMID: 2904701
2. Georgescu, M., et al. 2006. Pharmacol. Biochem. Behav. 83: 333-341. PMID: 16580057
3. Lee, S.H., et al. 2010. J Neurophysiol. PMID: 20107128

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), acetone, methanol, DMF, and water (0.3 mg/ml).
Storage :
Store at room temperature
Melting Point :
>300° C
Boiling Point :
~535.84° C (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKa: 4.38 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VD2180000
PubChem CID :
3899541
MDL Number :
MFCD00069257
SMILES :
C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])NC(=O)C(=O)N2

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

6,7-Dinitroquinoxaline-2,3-dione (DNQX)  Product Citations

See how others have used 6,7-Dinitroquinoxaline-2,3-dione (DNQX). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 19179335  Graziane, NM. et al. 2009. J. Biol. Chem. 284: 8329-8336.

PMID: # 17308309  De Felice, FG. et al. 2007. J. Biol. Chem. 282: 11590-11601.

PMID: # 15710623  Li, W. et al. 2005. J. Biol. Chem. 280: 18179-18188.

PMID: # 15755731  Madden, DR. et al. 2005. J. Biol. Chem. 280: 23637-23642.

PMID: # 12393911  Sanna, B. et al. 2002. J. Biol. Chem. 277: 49585-49590.

PMID: # 10542287  Alirezaei, M. et al. 1999. J. Biol. Chem. 274: 32433-32438.

Citations 1 to 6 of 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 60ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Graziane et al Graziane et al. (PubMed ID 19179335) used 6,7-Dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA receptor complex antagonist, to perform electrophysical recordings of synaptic currents. -SCBT Publication Review
Date published: 2015-06-03
  • y_2019, m_11, d_10, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200444, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 4ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.