5(S),6(R)-DiHETECAS: 82948-88-7
MF: C20H32O4
MW: 336.50
A LTD4 receptor agonist.

5(S),6(R)-DiHETE (CAS 82948-88-7)

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Application: A LTD4 receptor agonist
CAS Number: 82948-88-7
Molecular Weight: 336.50
Molecular Formula: C20H32O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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5(S),6(R)-DiHETE is an enzymatic metabolite of leukotriene A4 that functions as a CysLT1 Receptor (LTD4 (sc-201048) receptor) agonist. Studies show that the activation of the CysLT1 Receptor results in the contraction of lung parenchyma cells. In addition, it is the vicinal diol's specific structure that is essential for binding to the CysLT1 Receptor since other stereoisomers of the agonist do not bind to the receptor. These contractions in lung parenchyma cells are readily inhibited by FPL 55712 (sc-203583).


1. Borgeat, P., et al. 1979. J. Biol. Chem. 254: 7865-7869. PMID: 468794
2. Sirois, P., et al. 1982. Prostaglandins. 24: 405-418. PMID: 6296925
3. Haeggström, J., et al. 1986. J. Biol. Chem. 261: 6332-6337. PMID: 3009453
4. Haeggström, J., et al. 1988. Biochim. Biophys. Acta. 958: 469-476. PMID: 2829972
5. Muller, A., et al. 1989. Prostaglandins. 38: 635-644. PMID: 2633210

Formulation :
50 µg/ml in ethanol
Appearance :
Physical State :
Solubility :
Soluble in water (>1 mg/ml) at 25° C, PBS pH 7.2, ethanol, DMSO, and DMF.
Storage :
Store at -80° C
Boiling Point :
78° C
IC50 :
LTB4 induced neutrophil: IC50 = 8 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :

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Certificate of Analysis

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