5′-O-tert-Butyldimethylsilylthymidine (CAS 40733-28-6)
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5′-O-Tert-butyldimethylsilylthymidine (5-TBDMS-T) represents a modified version of thymidine, a nucleoside prominently present in DNA and RNA. This modified variant, 5′-O-Tert-butyldimethylsilylthymidine, has garnered considerable attention in scientific experiments owing to its remarkable adaptability to be modified with a wide array of functional groups. Additionally, it serves as a valuable substrate for techniques like polymerase chain reaction (PCR) and other nucleic acid amplification methods. Similar to its unmodified counterpart, 5′-O-Tert-butyldimethylsilylthymidine operates through a mechanism akin to thymidine. During replication, it becomes incorporated into DNA and RNA strands, fulfilling its role in the synthesis of these nucleic acids. Moreover, it serves as a substrate for enzymes involved in the metabolism of DNA and RNA, further contributing to its significance in cellular processes.
5′-O-tert-Butyldimethylsilylthymidine (CAS 40733-28-6) References
- Synthesis of 3'-C-substituted thymidine derivatives by free-radical techniques: scope and limitations. | Horton, D., et al. 2007. Carbohydr Res. 342: 259-67. PMID: 17173879
- Solvent-controlled regioselective protection of 5'-O-protected thymidine. | Teste, K., et al. 2008. Carbohydr Res. 343: 1490-5. PMID: 18479677
- Design and synthesis of α-carboxy phosphononucleosides. | Debarge, S., et al. 2011. J Org Chem. 76: 105-26. PMID: 21121618
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5′-O-tert-Butyldimethylsilylthymidine, 1 g | sc-262736 | 1 g | $177.00 | |||
5′-O-tert-Butyldimethylsilylthymidine, 5 g | sc-262736A | 5 g | $421.00 |