5′-N-Ethylcarboxamidoadenosine is a potent Adenosine A Receptor agonist (Ki values are 14, 20 and 6.2 nM for human Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R, respectively; EC50 = 2.4 μM for human Adenosine A2B-R). 5′-N-Ethylcarboxamidoadenosine also inhibits platelet aggregation.
Williams,M. "Adenosine - a selective neuromodulator in the mannalian CNS?" TINS, p.164 (May 1984) Cusack,N.J., Hourani, S.M.O. "5'-N-Ethylcarboxamidoadenosine - a potent inhibitor of human platelet aggregation." Br. J. Pharmacol. v. 72, 443 (1981) Bruns,R.F., Lu,G.H., Pugsley,T.A. "Characterization of the A2 adenosine receptor labeled by [3H]-NECA in rat striatal membranes." Mol. Pharmacol. v. 29, 331-46 (1986)
Soluble in water (slightly soluble), DMSO (14 mg/mL), 0.1 N HCl (3.4 mg/mL), ethanol (sparingly soluble), and 45% (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin (0.2 mg/mL).Solutions may be stored for several days at 4oC
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DuDu, X. et al. (PubMed 25966978) used the adenosine A receptor agonist 5'-N-Ethylcarboxamidoadenosine to stimulate angiogenesis by inducing VEGF and eNOS in human microvascular endothelial cells. -SCBT Publication Review
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