5′-Fluoroindirubinoxime (CAS 861214-33-7)

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Application: 5′-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FLT3

CAS Number: 861214-33-7

Molecular Weight: 295.27

Molecular Formula: C₁₆H₁₀FN₃O₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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5′-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3). This compound has been shown to be selective for FMT3 against 6 other kinases including EGFR.

References

1. Kim, S.A., et al. 2007. Clin. Cancer Res. 13: 253-359. PMID: 17200363
2. Krivogorsky, B., et al. 2008. Antimicrob. Agents Chemother. 52: 4466-4469. PMID: 18824607
3. Choi, S.J., et al. 2010. Bioorg. Med. Chem. Lett. 20: 2033-2037. PMID: 20153646

Physical State :

Solid

Solubility :

Soluble in DMSO (100 mM).

Storage :

Store at 4° C

IC50 :

Flt-3/Flk-2: IC₅₀ = 15 nM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

11580208

SMILES :

C1=CC=C2C(=C1)C(=C(N2)C3=C4C=C(C=CC4=NC3=O)F)NO

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Certificate of Analysis

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5′-Fluoroindirubinoxime (CAS 861214-33-7)

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References

Download SDS (MSDS)

Certificate of Analysis