5prime-Fluoroindirubinoxime CAS: 861214-33-7
MF: C16H10FN3O2
MW: 295.27
An antiproliferative agent and an inhibitor of FLT3.

5′-Fluoroindirubinoxime (CAS 861214-33-7)

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Application: 5′-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FLT3
CAS Number: 861214-33-7
Molecular Weight: 295.27
Molecular Formula: C16H10FN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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5′-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3). This compound has been shown to be selective for FMT3 against 6 other kinases including EGFR.


References

1. Kim, S.A., et al. 2007. Clin. Cancer Res. 13: 253-359. PMID: 17200363
2. Krivogorsky, B., et al. 2008. Antimicrob. Agents Chemother. 52: 4466-4469. PMID: 18824607
3. Choi, S.J., et al. 2010. Bioorg. Med. Chem. Lett. 20: 2033-2037. PMID: 20153646

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
IC50 :
Flt-3/Flk-2: IC50 = 15 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=CC=C2C(=C1)C(=C(N2)C3=C4C=C(C=CC4=NC3=O)F)NO

Download SDS (MSDS)

Certificate of Analysis

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