5′,6′-Epoxyeicosatrienoic acidA potent vasodilator and TRPV4 agonist

5′,6′-Epoxyeicosatrienoic acid (CAS 87173-80-6)

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Synonym: (±)5(6)-EET; (±)5,6-Epoxyeicosa-8Z,11Z,14Z-trienoic acid
Application: A potent vasodilator and TRPV4 agonist
CAS Number: 87173-80-6
Molecular Weight: 320.47
Molecular Formula: C20H32O3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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5′,6′-Epoxyeicosatrienoic acid can mobilizes calcium in anterior pituitary cells, stimulates insulin in rat pancreatic islets, and a potent stimulator of prolactin secretion. 5′,6′-Epoxyeicosatrienoic acid is also a potent vasodilator in the intestinal and cerebral microcirculation as well as in bovine coronary arteries. This compound is an endogenous TRPV4 agonist (Ki= 150nM).

Usage :
For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. After opening, prepare aliquots and store at -80°C.
Protect from air.
Formulation :
A solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in 100% ethanol (50 mg/ml), DMSO, DMF, and PBS, pH 7.2 (1 mg/ml).
Storage :
Store at -80° C
Boiling Point :
57° C
Refractive Index :
n20D 1.50 (Predicted)
Ki Data :
TRPV4: Ki= 150 nM
pK Values :
pKa: 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5283202
SMILES :
CCCCC/C=C\\C/C=C\\C/C=C\\CC1C(O1)CCCC(=O)O

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5′,6′-Epoxyeicosatrienoic acid  Product Citations

See how others have used 5′,6′-Epoxyeicosatrienoic acid. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26673139  Galindo-Villegas, J. et al. 2016. J. Immunol. 196: 738-49.

Citations 1 to 1 of 1 total

What is the exact volume of the sample of 50 micrograms of 5',6'-Epoxyeicosatrienoic acid? Since it comes in a solution of methyl acetate, I would like to know the exact volume to calculate my dilutions.

Asked by: MiriamHM
This is currently provided in a volume of 500 ul.
Answered by: Technical Support
Date published: 2018-12-11
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