5-Sulfosalicylic acid dihydrateCAS: 5965-83-3
MF: C7H6O6S 2H2O
MW: 254.2
For reducing and fixation of proteins in agarose and polyacrylamide gels.
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5-Sulfosalicylic acid dihydrate (CAS 5965-83-3)

5-Sulfosalicylic acid dihydrate | CAS 5965-83-3 is rated 5.0 out of 5 by 1.
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Application: For reducing and fixation of proteins in agarose and polyacrylamide gels
CAS Number: 5965-83-3
Purity: ≥99%
Molecular Weight: 254.2
Molecular Formula: C7H6O6S 2H2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. Strong association with a range of metals makes 5-Sulfosalicylic acid useful as a metal scavenger. It forms proton-transfer dye complexes with diazo compounds such as 4-(phenyldiazenyl)aniline. Proteins are precipitated upon complexation with 5-Sulfosalicylic acid, allowing qualitative analysis of the resultant turbidity formed in a sample by these complexes leaving solution. Protein precipitation with 5-Sulfosalicylic acid has also been employed as a preparative measure for removing proteins prior to chromatographic analysis.


References

1. Swatland, H.J. 1979. Stain Technol. 54: 245-249. PMID: 93325
2. Slørdal, L., et al. 1993. Ther Drug Monit. 15: 328-333. PMID: 8236369
3. Demoz, A., et al. 1995. J. Chromatogr. B, Biomed. Appl. 667: 148-152. PMID: 7663677
4. Buchmeiser, M.R ., et al. 2000. Anal. Chem. 72: 2595-2602. PMID: 10857641
5. Türkel, N. and Ozer, U. 2000. Chem. Pharm. Bull. 48: 870-872. PMID: 10866151
6. Foti, C., et al. 2002. Ann Chim. 92: 551-562. PMID: 12125460
7. Smith, G., et al. 2009. Acta Crystallogr C. 65: o543-o548. PMID: 19805891

Appearance :
Crystalline powder and crystalline
Physical State :
Solid
Solubility :
Soluble in water (127.1 mg/ml at 20° C), alcohol (very), ether, and polar solvents (generally).
Storage :
Store at room temperature
Melting Point :
105-110° C (lit.)
Boiling Point :
>120° C (dec.)
Density :
10.8 g/cm3 at 20° C
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
CA II: IC50 = 0.29 mM (human); CA I: IC50 = 0.42 mM (human)
Ki Data :
CA I: Ki= 0.77 mM (human); CA II: Ki= 1.92 mM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VO6500000
PubChem CID :
2723734
Merck Index :
14: 8964
MDL Number :
MFCD00149540
EC Number :
202-555-6
Beilstein Registry :
650741
SMILES :
O.O.OC(=O)C1=C(O)C=CC(=C1)S(O)(=O)=O

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Certificate of Analysis

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5-Sulfosalicylic acid dihydrate  Product Citations

See how others have used 5-Sulfosalicylic acid dihydrate. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 12361740  Chin, DL. et al. 2002. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 779: 259-269.

PMID: # 18967686  Shiobara, T. et al. 1999. Talanta. 49: 1083-1089.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Chin Chin, DL. et al. (PubMed 12361740) used 5-Sulfosalicylic acid dihydrate to precipitate out doxorubicin (Doxil) derived from PEGylated liposomal Doxil. -SCBT Publication Review
Date published: 2015-05-17
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