5(S),6(R)-7-trihydroxymethyl Heptanoate

5(S),6(R)-7-trihydroxymethyl Heptanoate (CAS 78606-80-1)

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Synonym: 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
Application: A potent lipoxin A4 agonist
CAS Number: 78606-80-1
Molecular Weight: 192.2
Molecular Formula: C8H16O5
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid by an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP). 5(S),6(R)-7-trihydroxymethyl heptanoate is a C-7 truncated analog of LXA4 that is equiactive as LXA4 in inhibition of LTB4-induced PMN chemotaxis with an IC50 of 5nM.


References

1 Lee, T.H., Lympany, P., Crea, A.E.G., et al. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships. Biochem Biophys Res Commun 180(3) 1416-1421 (1991).

Formulation :
A solution in methanol
Physical State :
Liquid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1230, Class 3 (6.1), Packing group II
PubChem CID :
10899465
SMILES :
COC(=O)CCC[C@@H]([C@@H](CO)O)O

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