Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid by an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP). 5(S),6(R)-7-trihydroxymethyl heptanoate is a C-7 truncated analog of LXA4 that is equiactive as LXA4 in inhibition of LTB4-induced PMN chemotaxis with an IC50 of 5nM.
1 Lee, T.H., Lympany, P., Crea, A.E.G., et al. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships. Biochem Biophys Res Commun 180(3) 1416-1421 (1991).
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