5-Nitro-alpha-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide CAS: 355022-97-8
MF: C18H15N3O4
MW: 337.33
A GABAA α2 agonist.

5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide (CAS 355022-97-8)

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Alternate Names: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H -indole-3-acetamide
Application: TCS 1205 is a GABAA α2 agonist
CAS Number: 355022-97-8
Purity: >99%
Molecular Weight: 337.33
Molecular Formula: C18H15N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TCS 1205 is reported to be a GABAA α1 partial agonist and GABAA α2 agonist in vitro.


References

1. Da Settimo, F., et al. 2001. J. Med. Chem. 44: 4359-4369. PMID: 11728182
2. Taliani, S., et al. 2009. J. Med. Chem. 52: 3723-3734. PMID: 19469479

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Optical Activity :
α20D -45.7°, c = 1.2 in DMF
Ki Data :
GABAA α2: Ki= 14 nM; GABAA α1: Ki= 121 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C[[email protected]@H](NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+](=O)[O-])c1ccc

Download SDS (MSDS)

Certificate of Analysis

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