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5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) is a potent Cl- channel blocker, identified through an optimization study of the diphenylamine-2-carboxylate core which demonstrates the basic Cl- channel blocking activity. NPPB also demonstrates suppression of prostaglandin E2 release with an IC50 of 8 μM, presumed to be a Cox (cyclooxygenase) inhibitor given its structural similarity to fenamic acid-type Cox inhibitors. It is also a GPR35 activator.
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See how others have used 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB). Click on the entry to view the PubMed entry .
PMID: # 31513788 2019. Neuropharmacology. 160: 107776.
PMID: # 31483794 2019. PLoS Negl Trop Dis. 13: e0007703.
PMID: # 26965147 Hayashi, M. et al. 2016. Pflugers Arch.
PMID: # 25855082 Pujol-Giménez, J. et al. 2015. Am. J. Physiol., Cell Physiol. 308: C1008-22.
PMID: # 25160132 Maloney, JM. et al. 2014. Soft Matter. 10: 8031-42.
PMID: # 23325449 Kasim, NR. et al. 2013. Apoptosis : an international journal on programmed cell death. 18: 521-32.
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