5-Methylchrysene is a member of the methylated chrysene (MeChry) compounds that acts as an aryl hydrocarbon receptor (AhR) activator. 5-Methylchrysene is a potential carcinogenic agent.
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YouYou, L. et al. (PubMed 7955114) evaluated the carcinogenic potential of 5-Methylchrysene (5-MeC) in strain A/J mouse lung and to correlate the 5-MeC-DNA adduct profile in lung tissue with the mutation spectrum in the K-ras gene of lung tumors. 5-MeC was found to be a potent lung carcinogen in strain A/J mice, inducing more than 100 tumors/mouse at a concentration of 200 mg/kg. Six 5-MeC-DNA adducts were observed; one adduct comigrated with the standard N2-deoxyguanosine adduct of 5-MeC-diol-epoxide I [1R,2S,3S-trihydroxy-4R-(N2-deoxy-guanosyl-3'-phosphate)- 1,2,3,4-tetrahydro-5-methyl-chrysene], derived from the bay-region diol-epoxide of 5-MeC. -SCBT Publication Review
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