5-IODO-A-85380 dihydrochloride CAS: 213764-92-2
MF: C9H11IN2O•2HCl
MW: 363.03
A subtype-selective agonist for AChR.

5-IODO-A-85380 dihydrochloride (CAS 213764-92-2)

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Application: 5-IODO-A-85380 dihydrochloride is a subtype-selective agonist for AChR
CAS Number: 213764-92-2
Purity: ≥98%
Molecular Weight: 363.03
Molecular Formula: C9H11IN2O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

5-IODO-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for AChR α4β2 and AChR α6β2. It activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). 5-IODO-A-85380 dihydrochloride is ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle AChR, respectively.


References

1. Koren, A.O., et al. 1998. J. Med. Chem. 41: 3690-3698. PMID: 9733494
2. Mukhin, A.G., et al. 2000. Mol. Pharmacol. 57: 642-649. PMID: 10692507
3. Mogg, A.J., et al. 2004. Neuropharmacology. 47: 848-859. PMID: 15527819

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at -20° C
Melting Point :
232-238° C
Boiling Point :
425.2° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.29
IC50 :
α6β2 nicotinic acetylcholine receptor : EC5050 = 12.7 nM (rat); α4β2 nicotinic acetylcholine receptor: EC5050 = ~35 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
53420768
MDL Number :
MFCD03791315
SMILES :
C1CNC1COC2=CC(=CN=C2)I.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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