5-Hydroxydecanoate sodium saltAn inhibitor of ATP-sensitive K+ channels

5-Hydroxydecanoate sodium salt (CAS 71186-53-3)

5-Hydroxydecanoate sodium salt | CAS 71186-53-3 is rated 5.0 out of 5 by 1.
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Synonym: 5-Hydroxycapric acid sodium salt; 5-Hydroxydecanoic acid sodium salt
Application: An inhibitor of ATP-sensitive K+ channels
CAS Number: 71186-53-3
Purity: ≥98%
Molecular Weight: 210.25
Molecular Formula: C10H19O3•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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5-Hydroxydecanoate Na (5-HD) is a substrate for mitochondrial outer membrane ACSL (acyl-CoA synthetase) that inhibits ATP-sensitive K+ channels. In neuronal type K sensitive ATP channel currents, 5-Hydroxydecanoate Na diminished the produced activation of the channels by PKG. On perfused rat hearts, 5-Hydroxydecanoate Na has shown the ability to inhibit the toxicity of 6-hyrdoxydopamine on dopaminergic neurons. 5-Hydroxydecanoate Na has displayed a lack of activity in inhibiting oxygen consuming mitochondria derived from skeletal muscle.


References

1. Notsu, T., et al. 1992. J. Pharmacol. Exp. Ther. 260: 702-708. PMID: 1738118
2. Rodriguez-Pallares, J., et al. 2009. Neurotox Res. 15: 82-95. PMID: 19384591
3. Chai, Y., et al. 2010. Am. J. Physiol., Cell Physiol. 298: C875-C892. PMID: 20053925
4. Li, X., et al. 2010. Biochim. Biophys. Acta. 1800: 385-391. PMID: 19931596
5. Montoya-Pérez, R., et al. 2010. J. Bioenerg. Biomembr. 42: 21-27. PMID: 20066482
6. Botha, P., et al. 2010. Transplantation. 89: 169-177. PMID: 20098279

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), and ethanol (10 mg/ml).
Storage :
Store at -20° C
Melting Point :
154-155° C
Refractive Index :
n20D 1.47 (Predicted)
pK Values :
pKa: 4.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23676659
MDL Number :
MFCD00153808
SMILES :
CCCCCC(CCCC(=O)[O-])O.[Na+]

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Certificate of Analysis

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5-Hydroxydecanoate sodium salt  Product Citations

See how others have used 5-Hydroxydecanoate sodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 15513944  Hanley, PJ. et al. 2005. J. Physiol. (Lond.). 562: 307-318.

PMID: # 12154175  Hanley, PJ. et al. 2002. J. Physiol. (Lond.). 542: 735-741.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Hanley Hanley, et. al. (PubMed ID 15513944) concluded in their study utilizing 5-HD (made in lab) that it should no longer be utilized as a useful tool to study the role of mitochondrial K(ATP) channels in pharmacological and ischaemic pre-conditioning as it has very complex metabolic effects. -SCBT Publication Review
Date published: 2015-03-23
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