Molecular structure of 5-Hydroxy Flunixin, CAS Number: 75369-61-8�
5-Hydroxy Flunixin (CAS 75369-61-8)
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Alternate Names:
5-Hydroxy Flunixin is known as a Flunixin metabolite.
Application:
5-Hydroxy Flunixin is the main metabolite of Flunixin, a non-steroidal anti-inflammatory nicotinic acid derivative.
CAS Number:
75369-61-8
Purity:
≥95%
Molecular Weight:
312.24
Molecular Formula:
C14H11F3N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Hydroxy Flunixin is a metabolite of flunixin, studied in the context of chemical metabolism and kinetics research. Researchers utilize this compound to understand the metabolic pathways of flunixin by identifying and quantifying its metabolites. The hydroxylation at the fifth position is an important phase I metabolic reaction, often mediated by liver enzymes such as cytochromes P450. In environmental science, 5-Hydroxy Flunixin is monitored as a potential environmental contaminant, reflecting the metabolism of flunixin and its subsequent excretion. Additionally, this metabolite is used in analytical studies to develop and validate sensitive methodologies for detecting the presence of flunixin and its metabolites in biological samples, employing advanced techniques like liquid chromatography-mass spectrometry (LC-MS).
5-Hydroxy Flunixin (CAS 75369-61-8) References
- Development of a rapid, multi-class method for the confirmatory analysis of anti-inflammatory drugs in bovine milk using liquid chromatography tandem mass spectrometry. | Malone, EM., et al. 2009. J Chromatogr A. 1216: 8132-40. PMID: 19467664
- Confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by high-performance liquid chromatography with fluorescence detection. | Gallo, P., et al. 2010. J Chromatogr A. 1217: 2832-9. PMID: 20227702
- Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue. | Gentili, A., et al. 2012. Anal Bioanal Chem. 404: 1375-88. PMID: 22777033
- Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle. | Kissell, LW., et al. 2012. J Dairy Sci. 95: 7151-7. PMID: 23040013
- Comparison of ELISA and LC-MS/MS for the measurement of flunixin plasma concentrations in beef cattle after intravenous and subcutaneous administration. | Shelver, WL., et al. 2013. J Agric Food Chem. 61: 2679-86. PMID: 23470029
- Occurrence of flunixin residues in bovine milk samples from the USA. | Kissell, LW., et al. 2013. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30: 1513-6. PMID: 23789859
- Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus). | Leavens, TL., et al. 2014. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 31: 1506-21. PMID: 25082521
- Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis. | Kissell, LW., et al. 2015. J Am Vet Med Assoc. 246: 118-25. PMID: 25517334
- Screening and Confirmatory Analyses of Flunixin in Tissues and Bodily Fluids after Intravenous or Intramuscular Administration to Cull Dairy Cows with or without Lipopolysaccharide Challenge. | Shelver, WL., et al. 2016. J Agric Food Chem. 64: 336-45. PMID: 26695354
- In vitro subcellular characterization of flunixin liver metabolism in heifers, steers, and cows. | Shappell, NW., et al. 2019. Res Vet Sci. 123: 118-123. PMID: 30641470
- Pharmacokinetics and pharmacodynamics of intravenous and transdermal flunixin meglumine in alpacas. | Reppert, EJ., et al. 2019. J Vet Pharmacol Ther. 42: 572-579. PMID: 31353535
- Pharmacokinetic Parameters and Estimated Milk Withdrawal Intervals for Domestic Goats (Capra Aegagrus Hircus) After Administration of Single and Multiple Intravenous and Subcutaneous Doses of Flunixin Meglumine. | Smith, JS., et al. 2020. Front Vet Sci. 7: 213. PMID: 32509803
- Identification and characterization of the enzymes responsible for the metabolism of the non-steroidal anti-inflammatory drugs, flunixin meglumine and phenylbutazone, in horses. | Knych, HK., et al. 2021. J Vet Pharmacol Ther. 44: 36-46. PMID: 32757313
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Hydroxy Flunixin, 1 mg | sc-214327 | 1 mg | $343.00 | |||
5-Hydroxy Flunixin, 2.5 mg | sc-214327A | 2.5 mg | $634.00 | |||
5-Hydroxy Flunixin, 5 mg | sc-214327B | 5 mg | $1093.00 | |||
5-Hydroxy Flunixin, 10 mg | sc-214327C | 10 mg | $1930.00 |