5-Fluoroanthranilic AcidAn antimetabolite for the tryptophan pathway in yeast

5-Fluoroanthranilic Acid (CAS 446-08-2)

5-Fluoroanthranilic Acid | CAS 446-08-2 is rated 5.0 out of 5 by 1.
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Synonym: 2-Amino-5-fluorobenzoic Acid
Application: An antimetabolite for the tryptophan pathway in yeast
CAS Number: 446-08-2
Molecular Weight: 155.13
Molecular Formula: C7H6FNO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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5-Fluoroanthranilic Acid is used for the counterselection of TRP1. It is a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic via its antimetabolite conversion to 5-Fluorotryptophan.


References

Toyn, J.H., et al.: Yeast, 16, 553, 560 (2000)

Appearance :
Needles
Physical State :
Solid
Solubility :
Soluble in water (partly), methanol, DMSO, and ethanol.
Storage :
Store at -20° C
Melting Point :
181-183° C (lit.)
Refractive Index :
n20D 1.61 (Predicted)
pK Values :
pKa: 1.69
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
101412
MDL Number :
MFCD00055566
EC Number :
207-159-7
Beilstein Registry :
2803664
SMILES :
Fc1ccc(N)c(c1)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of 5 Various publications cite the use of 5-Fluoroanthranilic Acid as a counter-selection of TRP1. It is a commonly used genetic marker in yeast Saccharoyces Cerevisiae. -SCBT Publication Review
Date published: 2015-02-22
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