Date published: 2025-12-15

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5-DOXYL-stearic acid, free radical (CAS 29545-48-0)

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CAS Number:
29545-48-0
Molecular Weight:
384.57
Molecular Formula:
C22H42NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-DOXYL-stearic acid, free radical is primarily used in the field of biophysics and biochemistry for studying lipid bilayers and biological membranes. Its paramagnetic properties make it an excellent spin label for electron paramagnetic resonance (EPR) spectroscopy. Researchers utilize 5-DOXYL-stearic acid, free radical to investigate the dynamics, fluidity, and phase behavior of membrane lipids, as the EPR spectra provide information about the local environment of the spin label within the lipid structure. The compound is also used in studying protein-lipid interactions, which are critical for understanding the function of membrane proteins. Furthermore, its application extends to the examination of lipid rafts and the lateral organization of biological membranes. Due to the specificity of the location of the doxyl group on the stearic acid chain, 5-DOXYL-stearic acid, free radical allows for targeted investigations into the depth-dependent behavior of lipids in membrane models.


5-DOXYL-stearic acid, free radical (CAS 29545-48-0) References

  1. Structural elucidation and conformational properties of the toxin paralysin beta-Ala-Tyr.  |  Kyrikou, I., et al. 2003. J Pharm Biomed Anal. 31: 713-21. PMID: 12644198
  2. Delivery of drugs to cell membranes by encapsulation in PEG-PE micelles.  |  Wang, J., et al. 2012. J Control Release. 160: 637-51. PMID: 22405904
  3. Sensitivity enhancement and contrasting information provided by free radicals in oriented-sample NMR of bicelle-reconstituted membrane proteins.  |  Tesch, DM. and Nevzorov, AA. 2014. J Magn Reson. 239: 9-15. PMID: 24355622
  4. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly.  |  Lewinski, MK., et al. 2015. J Biol Chem. 290: 10919-33. PMID: 25759385
  5. Spectroscopic Characterization of Structural Changes in Membrane Scaffold Proteins Entrapped within Mesoporous Silica Gel Monoliths.  |  Zeno, WF., et al. 2015. ACS Appl Mater Interfaces. 7: 8640-9. PMID: 25849085
  6. Micelle-Triggered β-Hairpin to α-Helix Transition in a 14-Residue Peptide from a Choline-Binding Repeat of the Pneumococcal Autolysin LytA.  |  Zamora-Carreras, H., et al. 2015. Chemistry. 21: 8076-89. PMID: 25917218
  7. Structural determination of virus protein U from HIV-1 by NMR in membrane environments.  |  Zhang, H., et al. 2015. Biochim Biophys Acta. 1848: 3007-3018. PMID: 26362058
  8. Real-time measurements of milk fat globule membrane modulation during simulated intestinal digestion using electron paramagnetic resonance spectroscopy.  |  Alshehab, M., et al. 2019. Colloids Surf B Biointerfaces. 184: 110511. PMID: 31600680
  9. Effects of growth with ethanol on fermentation and membrane fluidity of Saccharomyces cerevisiae.  |  Lloyd, D., et al. 1993. Yeast. 9: 825-33. PMID: 8212890

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-DOXYL-stearic acid, free radical, 1 mg

sc-505955
1 mg
$498.00

5-DOXYL-stearic acid, free radical, 2 mg

sc-505955A
2 mg
$979.00

5-DOXYL-stearic acid, free radical, 25 mg

sc-505955B
25 mg
$8170.00