5,7-Dichlorokynurenic acid is a derivative of the excitatory amino acid kynurenic acid and an antagonist of the strychnine-insensitive glycine modulatory (co-agonist) binding site on the NMDA receptor. 5,7-Dichlorokynurenic acid is described to potently and noncompetitively antagonize NMDA-stimulated elevation of cytosolic Ca2+, accumulation of cGMP, and release of norepinephrine. 5,7-Dichlorokynurenic acid is an inhibitor of GluR.
1. Baron, B.M., et al. 1990. Mol. Pharmacol. 38: 554-561. PMID: 2172769 2. Leeson, P.D., et al. 1991. J. Med. Chem. 34: 1243-1252. PMID: 1826744
Soluble in DMSO (10 mg/ml), 1eq. NaOH (100 mM), ethanol (slightly soluble), and dilute aq. base. Insoluble in water.
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