5,7-Dichlorokynurenic acidCAS: 131123-76-7
MF: C10H5Cl2NO3
MW: 258.06
A potent NMDA receptor glycine binding site antagonist.

5,7-Dichlorokynurenic acid (CAS 131123-76-7)

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Application: A potent NMDA receptor glycine binding site antagonist
CAS Number: 131123-76-7
Molecular Weight: 258.06
Molecular Formula: C10H5Cl2NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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5,7-Dichlorokynurenic acid is a derivative of the excitatory amino acid kynurenic acid and an antagonist of the strychnine-insensitive glycine modulatory (co-agonist) binding site on the NMDA receptor. 5,7-Dichlorokynurenic acid is described to potently and noncompetitively antagonize NMDA-stimulated elevation of cytosolic Ca2+, accumulation of cGMP, and release of norepinephrine. 5,7-Dichlorokynurenic acid is an inhibitor of GluR.


References

1. Baron, B.M., et al. 1990. Mol. Pharmacol. 38: 554-561. PMID: 2172769
2. Leeson, P.D., et al. 1991. J. Med. Chem. 34: 1243-1252. PMID: 1826744

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), 1eq. NaOH (100 mM), ethanol (slightly soluble), and dilute aq. base. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
171.07° C (Predicted)
Boiling Point :
428.28° C at 760 mmHg (Predicted)
Density :
1.65 g/mL (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Glutamate NMDA receptor: IC50 = 46 nM (Rattus norvegicus)
Ki Data :
NMDA receptor: Ki= 79 nM; Glutamate (NMDA) receptor subunit zeta 1: Ki= 40 nM (Rattus norvegicus)
pK Values :
pKa: 3.30 (Predicted), pKb: 8.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1779
MDL Number :
MFCD11045951
SMILES :
C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl

Download SDS (MSDS)

Certificate of Analysis

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