5,6-dehydro Arachidonic AcidCAS: 58688-54-3
MF: C20H30O2
MW: 302.46
A 5-LO inhibitor.

5,6-dehydro Arachidonic Acid (CAS 58688-54-3)

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Application: A 5-LO inhibitor
CAS Number: 58688-54-3
Molecular Weight: 302.46
Molecular Formula: C20H30O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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5,6-dehydro Arachidonic Acid is an analog of arachidonic acid with an acetylene in the 5,6 position and an inhibitor of 5-LO (Ki = 15 μM in rat basophilic leukemia cells, IC50 = 10 μM In guinea pig leukocytes).


References

1 Kohyama, N., Nagata, T., Fujimoto, S., et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci Biotech Biochem 61 347-350 (1997). 2 Sok, D., Han, C., Pai, J., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun 107 101-108 (1982).

Formulation :
A solution in ethanol
Appearance :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (100 µg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), and ethanol.
Storage :
Store at -20° C
Boiling Point :
78° C
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
5-LO: IC50 = 10 µM (guinea pig)
Ki Data :
5-LO: Ki= 15 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
6443815
MDL Number :
MFCD00065715
SMILES :
CCCCC\\C=C/C\\C=C/C\\C=C/CC#CCCCC(O)=O

Download SDS (MSDS)

Certificate of Analysis

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