5,6-dehydro Arachidonic Acid is an analog of arachidonic acid with an acetylene in the 5,6 position and an inhibitor of 5-LO (Ki = 15 μM in rat basophilic leukemia cells, IC50 = 10 μM In guinea pig leukocytes).
1 Kohyama, N., Nagata, T., Fujimoto, S., et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci Biotech Biochem 61 347-350 (1997). 2 Sok, D., Han, C., Pai, J., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun 107 101-108 (1982).
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