5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide is a potent benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 μM (1), where IKK-ε is mostly expressed n immune cells and thought to play a role in immune response.
1 Bamborough, P., Christopher, J.A., Cutler, G.J., et al. 5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-e kinase. Biooganic & Medicinal Chemistry Letters 16 6236-6240 (2006).
Soluble in DMSO (~10 mg/ml), DMF (~1 mg/ml), and DMSO: PBS(pH7.2) (1:4) (~0.2 mg/ml).
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