5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acidA selective inhibitor of 15-hydroxy PGDH

5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid (CAS 78028-01-0)

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Synonym: CAY10397; CK47A
Application: A selective inhibitor of 15-hydroxy PGDH
CAS Number: 78028-01-0
Molecular Weight: 328.32
Molecular Formula: C17H16N2O5
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5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid is a selective inhibitor of 15-hydroxy PGDH (IC50 ~ 10 µM) which acts to prolong the lifetime and activity of endogenously produced prostaglandins in cell cultures. 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid has also been shown to oxidize the 15-hydroxyl group and hydrogenate the 13,14-double bond on prostaglandins, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity.


References

1. Berry, C N., et al., 1983. Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. Biochemical pharmacology. 32(19): 2863-71. PMID: 6138042

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CCOC(=O)c1ccc(cc1)/N=N/c2ccc(c(c2)CC(=O)O)O

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5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid  Product Citations

See how others have used 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27984728  Grabocka, E. et al. 2016. Cell. 167: 1803-1813.e12.

PMID: # 31253108  BMC Cancer. 19: 643.

Citations 1 to 2 of 2 total
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