5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid is a selective inhibitor of 15-hydroxy PGDH (IC50 ~ 10 µM) which acts to prolong the lifetime and activity of endogenously produced prostaglandins in cell cultures. 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid has also been shown to oxidize the 15-hydroxyl group and hydrogenate the 13,14-double bond on prostaglandins, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity.
1. Berry, C N., et al., 1983. Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. Biochemical pharmacology. 32(19): 2863-71. PMID: 6138042
See how others have used 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid. Click on the entry to view the PubMed entry .
PMID: # 27984728 Grabocka, E. et al. 2016. Cell. 167: 1803-1813.e12.
PMID: # 31253108 BMC Cancer. 19: 643.
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