4E1RCatAn inhibitor of protein translation

4E1RCat (CAS 328998-25-0)

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Application: An inhibitor of protein translation
CAS Number: 328998-25-0
Purity: ≥95%
Molecular Weight: 478.45
Molecular Formula: C28H18N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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4E1RCat is an inhibitor of protein translation that has been shown to prevent eIF4E:eIF4G and eIF4E:4E-BP1 interaction. This compound blocks assembly of the eIF4F complex and inhibits cap-dependent translation.


References

1. Cencic, R., et al. 2010. Proc. Natl. Acad. Sci. USA 108: 1046-1051. PMID: 21191102

Physical State :
Solid
Solubility :
Soluble in DMSO (≥5 mg/ml).
Storage :
Store at -20° C
Melting Point :
310.74° C (Predicted)
Boiling Point :
764.78° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
Induced myeloid leukemia cell differentiation protein Mcl-1: IC50 = 416.66 nM (human); G-protein coupled receptor 55: IC50 = <500 nM (human); Eukaryotic translation initiation factor 4E: IC50 = 3.93 µM (Mus musculus); Voltage-gated N-type calcium channel alpha-1B subunit: IC50 = 5.56 µM (human); Amyloid beta A4 precursor protein-binding family A member 1: IC50 = 5.56 µM (Rattus norvegicus); Nonstructural protein 1: IC50 = 6.04 µM (Influenza A virus); Envelope glycoprotein gp160: IC50 = 9.9 µM (Human immunodeficiency virus 1); Cap-dependent translation: IC50 = ~4 µM
pK Values :
pKa: 4.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16195554
MDL Number :
MFCD01931282
SMILES :
C1=CC=C(C=C1)C2=C/C(=C\C3=CC=C(O3)C4=CC=C(C=C4)[N+](=O)[O-])/C(=O)N2C5=CC=C(C=C5)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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