4-Phenyl-3-furoxancarbonitrile is able to activate GCS (soluble guanylate cyclase) by releasing nitric oxide with the aid of thiol cofactors. 4-Phenyl-3-furoxancarbonitrile has also been shown to inhibit platelet aggregation.
1. Ferioli, R., et al., 1995. A new class of furoxan derivatives as NO donors: mechanism of action and biological activity. British journal of pharmacology. 114(4): 816-20. PMID: 7773542
2. Medana, C., et al., 1994. Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation. Journal of medicinal chemistry. 37(25): 4412-6. PMID: 7996554
3. Liu, S X., et al., 1997. Nitric oxide donors: effects of S-nitrosoglutathione and 4-phenyl-3-furoxancarbonitrile on ocular blood flow and retinal function recovery. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 13(2): 105-14. PMID: 9090611
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.