4-Phenyl-3-furoxancarbonitrileA soluble guanylate cyclase activator

4-Phenyl-3-furoxancarbonitrile (CAS 125520-62-9)

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Synonym: Furoxan, RVC-589
Application: A soluble guanylate cyclase activator
CAS Number: 125520-62-9
Molecular Weight: 187.20
Molecular Formula: C9H5N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-Phenyl-3-furoxancarbonitrile is able to activate GCS (soluble guanylate cyclase) by releasing nitric oxide with the aid of thiol cofactors. 4-Phenyl-3-furoxancarbonitrile has also been shown to inhibit platelet aggregation.


References

1. Ferioli, R., et al., 1995. A new class of furoxan derivatives as NO donors: mechanism of action and biological activity. British journal of pharmacology. 114(4): 816-20. PMID: 7773542
2. Medana, C., et al., 1994. Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation. Journal of medicinal chemistry. 37(25): 4412-6. PMID: 7996554
3. Liu, S X., et al., 1997. Nitric oxide donors: effects of S-nitrosoglutathione and 4-phenyl-3-furoxancarbonitrile on ocular blood flow and retinal function recovery. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 13(2): 105-14. PMID: 9090611

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mg/ml), and DMSO (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
73-74° C
IC50 :
Platelet aggregation: IC50 = 200 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1756
MDL Number :
MFCD00270898
SMILES :
O[N]1=C(C#N)C(=NO1)C1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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