4-Methylhistamine dihydrochloride CAS: 36376-47-3
MF: C6H11N3•2HCl
MW: 198.09
An H4 receptor agonist.

4-Methylhistamine dihydrochloride (CAS 36376-47-3)

4-Methylhistamine dihydrochloride | CAS 36376-47-3 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
Application: 4-Methylhistamine dihydrochloride is a H4 receptor agonist
CAS Number: 36376-47-3
Purity: ≥98%
Molecular Weight: 198.09
Molecular Formula: C6H11N32HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity as compared to other human histamine receptor subtypes.


References

1. Lim, H.D., et al. 2005. J. Pharmacol. Exp. Ther. 314: 1310-1321. PMID: 15947036
2. Gbahou, F., et al. 2006. Br. J. Pharmacol 147; 744-754. PMID: 16432504

Physical State :
Solid
Solubility :
Soluble in water (50 mM).
Storage :
Store at room temperature
Ki Data :
H4 receptor: Ki= 7 nM
pK Values :
pKb: 9.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NI3505800
PubChem CID :
MDL Number :
MFCD09878232
SMILES :
CC1=C(N=CN1)CCN.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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4-Methylhistamine dihydrochloride (CAS 36376-47-3)  Product Citations

See how others have used 4-Methylhistamine dihydrochloride (CAS 36376-47-3). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 29863427  Ebenezer, AJ.|Prasad, K.|Rajan, S.|Thangam, EB.| et al. 2018. J. Recept. Signal Transduct. Res. 38: 204-212.

PMID: # 27400655  Ebenezer, AJ. et al. 2016. Journal of receptor and signal transduction research. 1-8.

PMID: # 24239643  2014. Life Sci. 94: 54-7.

PMID: # 24934979  Jemima, EA. et al. 2014. Mol. Immunol. 62: 19-28.

PMID: # 29858014  J. Pharmacol. Sci. 122-128.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Ahmad SF; et al Ahmad SF; et al. (PubMed ID: 25666529) determined that 4-Methylhistamine dihydrochloride increased expression in inflammatory mediators and signaling pathways, in in rat knees. -SCBT Publication Review
Date published: 2015-06-09
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