4-iodo-SAHA CAS: 1219807-87-0
MF: C14H19IN2O3
MW: 390.20
An HDAC1 and HDAC6 inhibitor.

4-iodo-SAHA (CAS 1219807-87-0)

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Alternate Names: 4-Iodo suberoylanilide hydroxamic acid
Application: 4-iodo-SAHA is an HDAC1 and HDAC6 inhibitor
CAS Number: 1219807-87-0
Molecular Weight: 390.20
Molecular Formula: C14H19IN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA (sc-220139).


References

PMID: 20218673

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in 1:10 DMSO:PBS(pH7.2) (~0.1 mg/ml), EtOH (~0.2 mg/ml), DMSO (~30 mg/ml), and DMF (~30 mg/ml).
Storage :
Store at -20° C
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
U-937: EC5050 = 0.12 µM (human); HL-60: EC5050 = 0.85 µM (human); HT-29: EC5050 = 0.95 µM (human); SK-BR-3: EC5050 = 1.1 µM (human); K562: EC5050 = 1.3 µM (human)
pK Values :
pKa: 9.48 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=CC(=CC=C1NC(=O)CCCCCCC(=O)NO)I

Download SDS (MSDS)

Certificate of Analysis

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