4-hydroxy Nonenal Mercapturic Acid (CAS 146764-24-1)

4-Hydroxy Nonenal Mercapturic Acid, bearing the CAS number 146764-24-1, is a metabolite formed from the detoxification of 4-hydroxy-2-nonenal (4-HNE), a lipid peroxidation product known for its role in cellular oxidative stress. This compound specifically arises through the conjugation of 4-HNE with glutathione, a critical antioxidant in cellular defense mechanisms, facilitated by glutathione S-transferase enzymes. This process transforms reactive aldehydes into more water-soluble mercapturic acids, aiding in their excretion from the body. In research, 4-hydroxy nonenal mercapturic acid is extensively used as a biomarker to assess oxidative stress and the efficacy of detoxification pathways in various experimental settings. The compound′s presence and quantity can indicate the extent of lipid peroxidation and the oxidative burden within cells or tissues. Researchers utilize this biomarker in studies investigating the cellular responses to oxidative stress, environmental toxin exposure, and the mechanisms underlying the antioxidant defense system. By analyzing levels of 4-hydroxy nonenal mercapturic acid, insights into how cells mitigate damage caused by reactive oxygen species and maintain cellular integrity under stress are gained, contributing to a broader understanding of cellular health and resilience.