4-DAMP, or 4-diphenylacetoxy-N-methyl-piperidine methiodide, is an antagonist at muscarinic receptors. A deuterated [3H]4-DAMP derivative was demonstrated to bind mAChR M1 and mAChR M3 with high affinity, and mAChR M2 with low affinity. Blockade of mAChR M2 by 4-DAMP produced a dose-dependent reduction of blood pressure in spotaneously hypertensive rats. 4-DAMP is an inhibitor of mAChR M1, mAChR M2, mAChR M3, mAChR M4 and mAChR M5.
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See how others have used 4-DAMP (CAS 1952-15-4). Click on the entry to view the PubMed entry .
PMID: # 27576172 Liang, Z. et al. 2017. Neurourol. Urodyn. 36: 1261-1269.
PMID: # 25412212 Dai, Y. et al. 2015. Molecular medicine reports. 11: 2292-8.
PMID: # 23577721 Lu, X. et al. 2013. J. Cell. Mol. Med. 17: 664-71.
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