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4-Anilino-4-oxobutanoic Acid (CAS 102-14-7)

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Alternate Names:
Succinanilic acid; N-Phenyl-succinamic Acid; Butanedioic Acid Anilide
Application:
4-Anilino-4-oxobutanoic Acid is the metabolite of Suberoylanilide Hydroxamic Acid (Vorinostat)
CAS Number:
102-14-7
Molecular Weight:
193.20
Molecular Formula:
C10H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Anilino-4-oxobutanoic Acid, a compound known for its distinct chemical structure, plays a significant role in the realm of biochemical research, particularly in the study of enzyme-substrate interactions and the elucidation of reaction mechanisms within organic synthesis pathways. This compound, characterized by its combination of an aniline moiety attached to a 4-oxobutanoic acid backbone, serves as a tool in understanding the intricacies of enzyme kinetics and specificity. Its unique structure enables it to act as a mimic or inhibitor for certain biochemical reactions, providing invaluable insights into the binding affinities and structural requirements for enzyme activity. In research, 4-Anilino-4-oxobutanoic Acid is often utilized in the design of experiments aimed at dissecting the molecular underpinnings of catalytic processes, thereby offering a window into the molecular architecture of biological systems and contributing to the development of novel synthetic methodologies that can be applied in various fields of chemistry and biochemistry.


4-Anilino-4-oxobutanoic Acid (CAS 102-14-7) References

  1. High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum.  |  Du, L., et al. 2005. Rapid Commun Mass Spectrom. 19: 1779-87. PMID: 15945019
  2. A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum.  |  Parise, RA., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 840: 108-15. PMID: 16725386
  3. Stability studies of vorinostat and its two metabolites in human plasma, serum and urine.  |  Du, L., et al. 2006. J Pharm Biomed Anal. 42: 556-64. PMID: 16824724
  4. A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.  |  Rubin, EH., et al. 2006. Clin Cancer Res. 12: 7039-45. PMID: 17145826
  5. Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies.  |  Ramalingam, SS., et al. 2007. Clin Cancer Res. 13: 3605-10. PMID: 17510206
  6. Quantitative analysis of a proteome by N-terminal stable-isotope labelling of tryptic peptides.  |  Fedjaev, M., et al. 2007. Rapid Commun Mass Spectrom. 21: 2671-9. PMID: 17659651
  7. Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype.  |  Balliet, RM., et al. 2009. Cancer Res. 69: 2981-9. PMID: 19318555
  8. Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma.  |  Watanabe, T., et al. 2010. Cancer Sci. 101: 196-200. PMID: 19817748
  9. Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat.  |  Kerr, JS., et al. 2010. Int J Toxicol. 29: 3-19. PMID: 19903873
  10. Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer.  |  Wong, NS., et al. 2011. Pharmacogenet Genomics. 21: 760-8. PMID: 21849928
  11. Clinical pharmacology profile of vorinostat, a histone deacetylase inhibitor.  |  Iwamoto, M., et al. 2013. Cancer Chemother Pharmacol. 72: 493-508. PMID: 23820962
  12. Vorinostat in combination with bortezomib in patients with advanced malignancies directly alters transcription of target genes.  |  Kolesar, JM., et al. 2013. Cancer Chemother Pharmacol. 72: 661-7. PMID: 23903894
  13. Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood.  |  Liu, L., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 964: 212-21. PMID: 24636840
  14. Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine.  |  Suresh, PS., et al. 2017. Biomed Chromatogr. 31: PMID: 27511598

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Anilino-4-oxobutanoic Acid, 1 g

sc-216778
1 g
$229.00