4-Aminopyridine (4-AP) is a nonselective K+ channel blocker that has been used to characterize and study the blockage of K+ channels. Studies show that 4-AP binds from the cytoplasmic side of the cell membrane. Research suggests that 4-AP extends the potentials of unmyelinated and demyelinated fibers, facilitates conduction in fibers blocked by demyelination, and can induce glutamate and neurotransmitter γ-aminobutyric acid (GABA) release.
1. Sherratt, R.M., et al. 1980. Nature. 283: 570-572. PMID: 7354839 2. Bouchard, R., et al. 1995. J. Pharmacol. Exp. Ther. 275: 864-876. PMID: 7473178 3. Tseng, G.N. 1999. J. Pharmacol. Exp. Ther. 290: 569-577. PMID: 10411564 4. Westphalen, R.I., et al. 2010. J. Neurochem. 113: 1611-1620. PMID: 20374421
Powder or crystalline
Soluble in water (50 mg/ml), 100% ethanol, methanol (slightly), alcohol, and DMSO (100 mM).
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Rated 5 out of
Excellent quality every time.I have been purchasing from SCBT for two years now. The customer service and quality of the chemicals is always top notch. I am very satisfied.
The 4-Aminopyridine is excellent, as always. I shall have no hesitation in purchasing again.
Date published: 2016-12-19
Rated 5 out of
Westphalen et alWestphalen et al. (PubMed ID 20374421) found that 4-aminopyridine stimulated the release of 3H glutamate and 14C GABA to the Na(v) blocker TTX in the rat cerebral cortex. -SCBT Publication Review
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