4-AminopyridineA nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane

4-Aminopyridine (CAS 504-24-5)

4-Aminopyridine | CAS 504-24-5 is rated 5.0 out of 5 by 2.
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Synonym: 4-Pyridinamine; Fampridine
Application: A nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane
CAS Number: 504-24-5
Purity: ≥98%
Molecular Weight: 94.11
Molecular Formula: C5H6N2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-Aminopyridine (4-AP) is a nonselective K+ channel blocker that has been used to characterize and study the blockage of K+ channels. Studies show that 4-AP binds from the cytoplasmic side of the cell membrane. Research suggests that 4-AP extends the potentials of unmyelinated and demyelinated fibers, facilitates conduction in fibers blocked by demyelination, and can induce glutamate and neurotransmitter γ-aminobutyric acid (GABA) release.


References

1. Sherratt, R.M., et al. 1980. Nature. 283: 570-572. PMID: 7354839
2. Bouchard, R., et al. 1995. J. Pharmacol. Exp. Ther. 275: 864-876. PMID: 7473178
3. Tseng, G.N. 1999. J. Pharmacol. Exp. Ther. 290: 569-577. PMID: 10411564
4. Westphalen, R.I., et al. 2010. J. Neurochem. 113: 1611-1620. PMID: 20374421

Appearance :
Powder or crystalline
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), 100% ethanol, methanol (slightly), alcohol, and DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
155-158° C (lit.)
Boiling Point :
273° C (lit.)
Density :
1.26 g/cm3
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
KV1.1: IC50 = 170 µM; KV1.2: IC50 = 230 µM; Acetylcholinesterase: IC50 = >500 µM (rat)
Ki Data :
Choline transporter: Ki= 480.8 (mouse)
pK Values :
pKa: 9.17, pKb: 9.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
US1750000
PubChem CID :
1727
Merck Index :
14: 3933
MDL Number :
MFCD00006439
EC Number :
207-987-9
Beilstein Registry :
105782
SMILES :
C1=CN=CC=C1N

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4-Aminopyridine  Product Citations

See how others have used 4-Aminopyridine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27858307  Filatova, TS. et al. 2017. J. Physiol. Biochem. 73: 167-174.

PMID: # 10411564  Tseng, GN. et al. 1999. J. Pharmacol. Exp. Ther. 290: 569-577.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Excellent quality every time. I have been purchasing from SCBT for two years now. The customer service and quality of the chemicals is always top notch. I am very satisfied. The 4-Aminopyridine is excellent, as always. I shall have no hesitation in purchasing again.
Date published: 2016-12-19
Rated 5 out of 5 by from Westphalen et al Westphalen et al. (PubMed ID 20374421) found that 4-aminopyridine stimulated the release of 3H glutamate and 14C GABA to the Na(v) blocker TTX in the rat cerebral cortex. -SCBT Publication Review
Date published: 2015-06-15
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