4,5-diphenyl-1,2,3-Thiadiazole has diverse applications in medicine and agriculture, including acting as a bactericide, fungicide, and antiviral agent. It has been shown to selectively inhibit the CYP450 enzymes CYP2B4 and CYP1A2 at concentrations of up to 100 µM, but not CYP2E1.
1. Babu, B R., et al., 1997. 1,2,3-Thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry. 36(23): 7209-16. PMID: 9188722