Date published: 2025-10-14

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4,4-Dihydroxystilbene (CAS 659-22-3)

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Alternate Names:
Stilbene-4,4′-diol
CAS Number:
659-22-3
Molecular Weight:
212.24
Molecular Formula:
C14H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4,4-Dihydroxystilbene is an organic compound that has garnered interest in several research domains, most notably in materials science and analytical chemistry. Due to its structural similarity to other stilbenes that exhibit interesting optical properties, it is studied for its potential use in the development of organic electronic devices, such as organic light-emitting diodes (OLEDs). The hydroxyl groups in 4,4-Dihydroxystilbene make it a candidate for further chemical modifications, which can lead to the synthesis of new compounds with tailored electronic properties. It is also of interest in studies involving the design of organic photosensitizers, where its ability to absorb light and transfer energy is valuable in the field of photodynamic applications. Furthermore, 4,4-Dihydroxystilbene is used as a standard or reference compound in chromatographic analysis of stilbenoids, aiding in the identification and quantification of similar compounds in complex mixtures.


4,4-Dihydroxystilbene (CAS 659-22-3) References

  1. Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media.  |  Privat, C., et al. 2002. J Agric Food Chem. 50: 1213-7. PMID: 11853506
  2. Antitumor activities of synthetic and natural stilbenes through antiangiogenic action.  |  Kimura, Y., et al. 2008. Cancer Sci. 99: 2083-96. PMID: 19016770
  3. Structure-activity relationships of resveratrol and derivatives in breast cancer cells.  |  Lappano, R., et al. 2009. Mol Nutr Food Res. 53: 845-58. PMID: 19496085
  4. Antitumor and Antimetastatic Activity of Synthetic Hydroxystilbenes Through Inhibition of Lymphangiogenesis and M2 Macrophage Differentiation of Tumor-associated Macrophages.  |  Kimura, Y., et al. 2016. Anticancer Res. 36: 137-48. PMID: 26722037
  5. A One-Pot Cascade Reaction Combining an Encapsulated Decarboxylase with a Metathesis Catalyst for the Synthesis of Bio-Based Antioxidants.  |  Gómez Baraibar, Á., et al. 2016. Angew Chem Int Ed Engl. 55: 14823-14827. PMID: 27754591
  6. trans-4,4'-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines.  |  Saha, B., et al. 2017. Oncotarget. 8: 73905-73924. PMID: 29088756
  7. Resveratrol analogue, trans-4,4'-dihydroxystilbene (DHS), inhibits melanoma tumor growth and suppresses its metastatic colonization in lungs.  |  Saha, B., et al. 2018. Biomed Pharmacother. 107: 1104-1114. PMID: 30257322
  8. Ligand-controlled iridium-catalyzed semihydrogenation of alkynes with ethanol: highly stereoselective synthesis of E- and Z-alkenes.  |  Yang, J., et al. 2019. Chem Commun (Camb). 55: 1903-1906. PMID: 30675609
  9. Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response.  |  Wang, T., et al. 2020. Free Radic Biol Med. 152: 525-539. PMID: 31760092
  10. Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway.  |  Wang, CN., et al. 2020. Bioorg Chem. 104: 104295. PMID: 32987309
  11. Resveratrol and Its Analogue 4,4'-Dihydroxy-trans-stilbene Inhibit Lewis Lung Carcinoma Growth In Vivo through Apoptosis, Autophagy and Modulation of the Tumour Microenvironment in a Murine Model.  |  Savio, M., et al. 2022. Biomedicines. 10: PMID: 35892684
  12. Inhibition of Resveratrol Analogs on Human and Rat 3β-Hydroxysteroid Dehydrogenases: Structure-Activity Relationship and Docking Analysis.  |  Su, M., et al. 2023. J Agric Food Chem. 71: 7566-7574. PMID: 37129992
  13. Analysis of diethylstilbestrol and its impurities in tablets using reversed-phase high-performance liquid chromatography.  |  Lea, AR., et al. 1979. J Chromatogr. 177: 61-8. PMID: 536447
  14. Metabolic hydroxylations of trans-stilbene.  |  Sinsheimer, JE. and Smith, RV. 1969. Biochem J. 111: 35-41. PMID: 5775688

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4,4-Dihydroxystilbene, 5 mg

sc-358600
5 mg
$12.00

4,4-Dihydroxystilbene, 100 mg

sc-358600A
100 mg
$240.00